Literature DB >> 14558789

Protein surface recognition by rational design: nanomolar ligands for potassium channels.

Stefan N Gradl1, John P Felix, Ehud Y Isacoff, Maria L Garcia, Dirk Trauner.   

Abstract

The rational design and development of four-fold symmetrical ligands for potassium channels is described.

Mesh：

Substances：

Year:  2003        PMID： 14558789      PMCID： PMC1458372          DOI： 10.1021/ja036155z

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  18 in total

Review 1.  Potassium channels: from scorpion venoms to high-resolution structure.

Authors:  M L Garcia; Y Gao; O B McManus; G J Kaczorowski
Journal:  Toxicon       Date:  2001-06       Impact factor: 3.033

Review 2.  Pharmacology of voltage-gated and calcium-activated potassium channels.

Authors:  G J Kaczorowski; M L Garcia
Journal:  Curr Opin Chem Biol       Date:  1999-08       Impact factor: 8.822

3.  Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold.

Authors:  R K Jain; A D Hamilton
Journal:  Org Lett       Date:  2000-06-15       Impact factor: 6.005

4.  Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.

Authors:  Y Zhou; J H Morais-Cabral; A Kaufman; R MacKinnon
Journal:  Nature       Date:  2001-11-01       Impact factor: 49.962

5.  Peptide and protein recognition by designed molecules.

Authors:  M W Peczuh; A D Hamilton
Journal:  Chem Rev       Date:  2000-07-12       Impact factor: 60.622

Review 6.  Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.

Authors:  M J Coghlan; W A Carroll; M Gopalakrishnan
Journal:  J Med Chem       Date:  2001-05-24       Impact factor: 7.446

7.  Functional analysis of an archaebacterial voltage-dependent K+ channel.

Authors:  Vanessa Ruta; Youxing Jiang; Alice Lee; Jiayun Chen; Roderick MacKinnon
Journal:  Nature       Date:  2003-03-02       Impact factor: 49.962

8.  A snake toxin inhibitor of inward rectifier potassium channel ROMK1.

Authors:  J P Imredy; C Chen; R MacKinnon
Journal:  Biochemistry       Date:  1998-10-20       Impact factor: 3.162

9.  Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3.

Authors:  J P Felix; R M Bugianesi; W A Schmalhofer; R Borris; M A Goetz; O D Hensens; J M Bao; F Kayser; W H Parsons; K Rupprecht; M L Garcia; G J Kaczorowski; R S Slaughter
Journal:  Biochemistry       Date:  1999-04-20       Impact factor: 3.162

10.  Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom.

Authors:  A Koschak; R M Bugianesi; J Mitterdorfer; G J Kaczorowski; M L Garcia; H G Knaus
Journal:  J Biol Chem       Date:  1998-01-30       Impact factor: 5.157
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  17 in total

Review 1.  K+ channels as targets for specific immunomodulation.

Authors:  K George Chandy; Heike Wulff; Christine Beeton; Michael Pennington; George A Gutman; Michael D Cahalan
Journal:  Trends Pharmacol Sci       Date:  2004-05       Impact factor: 14.819

Review 2.  Targeting protein-protein interactions by rational design: mimicry of protein surfaces.

Authors:  Steven Fletcher; Andrew D Hamilton
Journal:  J R Soc Interface       Date:  2006-04-22       Impact factor: 4.118

Review 3.  Knitting and untying the protein network: modulation of protein ensembles as a therapeutic strategy.

Authors:  Susana Gordo; Ernest Giralt
Journal:  Protein Sci       Date:  2009-03       Impact factor: 6.725

4.  Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates.

Authors:  Rishi K Jain; Lun K Tsou; Andrew D Hamilton
Journal:  Tetrahedron Lett       Date:  2009-06-10       Impact factor: 2.415

Review 5.  K+ channel modulators for the treatment of neurological disorders and autoimmune diseases.

Authors:  Heike Wulff; Boris S Zhorov
Journal:  Chem Rev       Date:  2008-05       Impact factor: 60.622

Review 6.  Discovery of KV 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges.

Authors:  Špela Gubič; Louise A Hendrickx; Žan Toplak; Maša Sterle; Steve Peigneur; Tihomir Tomašič; Luis A Pardo; Jan Tytgat; Anamarija Zega; Lucija P Mašič
Journal:  Med Res Rev       Date:  2021-05-01       Impact factor: 12.944

7.  Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.

Authors:  Christine Beeton; Michael W Pennington; Heike Wulff; Satendra Singh; Daniel Nugent; George Crossley; Ilya Khaytin; Peter A Calabresi; Chao-Yin Chen; George A Gutman; K George Chandy
Journal:  Mol Pharmacol       Date:  2005-01-21       Impact factor: 4.436

8.  Molecular tweezers modulate 14-3-3 protein-protein interactions.

Authors:  David Bier; Rolf Rose; Kenny Bravo-Rodriguez; Maria Bartel; Juan Manuel Ramirez-Anguita; Som Dutt; Constanze Wilch; Frank-Gerrit Klärner; Elsa Sanchez-Garcia; Thomas Schrader; Christian Ottmann
Journal:  Nat Chem       Date:  2013-02-17       Impact factor: 24.427

9.  Surface binding inhibitors of the SCF-KIT protein-protein interaction.

Authors:  David Margulies; Yarden Opatowsky; Steven Fletcher; Ishu Saraogi; Lun K Tsou; Sourav Saha; Irit Lax; Joseph Schlessinger; Andrew D Hamilton
Journal:  Chembiochem       Date:  2009-08-17       Impact factor: 3.164

Review 10.  The functional network of ion channels in T lymphocytes.

Authors:  Michael D Cahalan; K George Chandy
Journal:  Immunol Rev       Date:  2009-09       Impact factor: 12.988
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