Literature DB >> 18476673

K+ channel modulators for the treatment of neurological disorders and autoimmune diseases.

Heike Wulff1, Boris S Zhorov.   

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Year:  2008        PMID： 18476673      PMCID： PMC2714671          DOI： 10.1021/cr078234p

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


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  397 in total

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2.  Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.

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Review 3.  Ion channels in microglia (brain macrophages).

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4.  Role of K+ channels in adrenal catecholamine secretion in anesthetized dogs.

Authors:  T Nagayama; K Masada; M Yoshida; M Suzuki-Kusaba; H Hisa; T Kimura; S Satoh
Journal:  Am J Physiol       Date:  1998-04

Review 5.  Potassium channels, memory T cells, and multiple sclerosis.

Authors:  Christine Beeton; K George Chandy
Journal:  Neuroscientist       Date:  2005-12       Impact factor: 7.519

6.  Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation.

Authors:  D A Fadool; I B Levitan
Journal:  J Neurosci       Date:  1998-08-15       Impact factor: 6.167

7.  IKir regulation in murine macrophages: whole cell and perforated patch studies.

Authors:  S I Judge; E Montcalm-Mazzilli; E K Gallin
Journal:  Am J Physiol       Date:  1994-12

8.  The beta subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding.

Authors:  M Hanner; R Vianna-Jorge; A Kamassah; W A Schmalhofer; H G Knaus; G J Kaczorowski; M L Garcia
Journal:  J Biol Chem       Date:  1998-06-26       Impact factor: 5.157

9.  Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia.

Authors:  T Bowen; C A Guy; N Craddock; A G Cardno; N M Williams; G Spurlock; K C Murphy; L A Jones; M Gray; R D Sanders; G McCarthy; K G Chandy; E Fantino; K Kalman; G A Gutman; J J Gargus; J Williams; P McGuffin; M J Owen; M C O'Donovan
Journal:  Mol Psychiatry       Date:  1998-05       Impact factor: 15.992

10.  Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.

Authors:  Paola Pedarzani; Jaime E McCutcheon; Gregor Rogge; Bo Skaaning Jensen; Palle Christophersen; Charlotte Hougaard; Dorte Strøbaek; Martin Stocker
Journal:  J Biol Chem       Date:  2005-10-20       Impact factor: 5.157
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  86 in total

1.  Targeting K(V) channels rescues retinal ganglion cells in vivo directly and by reducing inflammation.

Authors:  Paulo D Koeberle; Lyanne C Schlichter
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2.  Potassium channel block by a tripartite complex of two cationophilic ligands and a potassium ion.

Authors:  Pavel I Zimin; Bojan Garic; Silke B Bodendiek; Cédrick Mahieux; Heike Wulff; Boris S Zhorov
Journal:  Mol Pharmacol       Date:  2010-07-02       Impact factor: 4.436

Review 3.  Regulating Factors in Acid-Sensing Ion Channel 1a Function.

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Review 4.  Inhibiting bacterial toxins by channel blockage.

Authors:  Sergey M Bezrukov; Ekaterina M Nestorovich
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5.  Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity.

Authors:  Izumi Maezawa; Pavel I Zimin; Heike Wulff; Lee-Way Jin
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Review 6.  Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery.

Authors:  Ivica Grgic; Brajesh P Kaistha; Joachim Hoyer; Ralf Köhler
Journal:  Br J Pharmacol       Date:  2009-03-19       Impact factor: 8.739

Review 7.  The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases.

Authors:  Jenny Lam; Nichole Coleman; April Lourdes A Garing; Heike Wulff
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8.  A Novel Relationship for Schizophrenia, Bipolar, and Major Depressive Disorder. Part 8: a Hint from Chromosome 8 High Density Association Screen.

Authors:  Xing Chen; Feng Long; Bin Cai; Xiaohong Chen; Lizeng Qin; Gang Chen
Journal:  Mol Neurobiol       Date:  2016-09-22       Impact factor: 5.590

Review 9.  Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease.

Authors:  Ralf Köhler; Brajesh P Kaistha; Heike Wulff
Journal:  Expert Opin Ther Targets       Date:  2010-02       Impact factor: 6.902

10.  KCa3.1 constitutes a pharmacological target for astrogliosis associated with Alzheimer's disease.

Authors:  Mengni Yi; Panpan Yu; Qin Lu; Herbert M Geller; Zhihua Yu; Hongzhuan Chen
Journal:  Mol Cell Neurosci       Date:  2016-08-24       Impact factor: 4.314
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