Literature DB >> 20352130

Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates.

Rishi K Jain1, Lun K Tsou, Andrew D Hamilton.   

Abstract

A set of macrocycles was generated by solid phase synthesis of linear trimers of 5-aminoacyl-3-aminomethyl-benzoates followed by resin cleavage and solution phase macrocyclization. These scaffolds can serve as useful building blocks for molecular recognition studies, especially where differentially functionalized molecular platforms spanning large surface areas are required.

Entities:  

Year:  2009        PMID： 20352130      PMCID： PMC2843919          DOI： 10.1016/j.tetlet.2009.03.153

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  18 in total

1.  Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold.

Authors:  R K Jain; A D Hamilton
Journal:  Org Lett       Date:  2000-06-15       Impact factor: 6.005

Review 2.  Molecular recognition of DNA by small molecules.

Authors:  P B Dervan
Journal:  Bioorg Med Chem       Date:  2001-09       Impact factor: 3.641

3.  Peptide and protein recognition by designed molecules.

Authors:  M W Peczuh; A D Hamilton
Journal:  Chem Rev       Date:  2000-07-12       Impact factor: 60.622

Review 4.  The cluster glycoside effect.

Authors:  Joseph J Lundquist; Eric J Toone
Journal:  Chem Rev       Date:  2002-02       Impact factor: 60.622

5.  Protein surface recognition by rational design: nanomolar ligands for potassium channels.

Authors:  Stefan N Gradl; John P Felix; Ehud Y Isacoff; Maria L Garcia; Dirk Trauner
Journal:  J Am Chem Soc       Date:  2003-10-22       Impact factor: 15.419

6.  Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition.

Authors:  Jack D Sadowsky; Margaret A Schmitt; Hee-Seung Lee; Naoki Umezawa; Shaomeng Wang; York Tomita; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2005-08-31       Impact factor: 15.419

7.  Increasing the kinase specificity of k252a by protein surface recognition.

Authors:  Tanya L Schneider; Rebecca S Mathew; Kevin P Rice; Kazuhiko Tamaki; John L Wood; Alanna Schepartz
Journal:  Org Lett       Date:  2005-04-28       Impact factor: 6.005

8.  Selective disruption of protein aggregation by cyclodextrin dimers.

Authors:  D K Leung; Z Yang; R Breslow
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

9.  Cyclic homooligomers from sugar amino acids: synthesis, conformational analysis, and significance.

Authors:  E Locardi; M Stöckle; S Gruner; H Kessler
Journal:  J Am Chem Soc       Date:  2001-08-29       Impact factor: 15.419

10.  Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice.

Authors:  M A Blaskovich; Q Lin; F L Delarue; J Sun; H S Park; D Coppola; A D Hamilton; S M Sebti
Journal:  Nat Biotechnol       Date:  2000-10       Impact factor: 54.908
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  2 in total

Review 1.  Synthetic Receptors Based on Abiotic Cyclo(pseudo)peptides.

Authors:  Stefan Kubik
Journal:  Molecules       Date:  2022-04-28       Impact factor: 4.927

2.  Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers.

Authors:  Joseph W Meisel; Chunhua T Hu; Andrew D Hamilton
Journal:  Org Lett       Date:  2019-09-19       Impact factor: 6.005
  2 in total

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