| Literature DB >> 14535728 |
Merritt B Andrus1, Erik J Hicken, Erik L Meredith, Bryon L Simmons, John F Cannon.
Abstract
[structure: see text] The quinone portion of the ansamycin geldanamycin was made with complete selectivity from the 1,4-dihydroquinone generated from a 1,4-bis-methoxymethyl (MOM) ether intermediate. Palladium catalysis with air gave the desired product in 98% isolated yield. The structure was established using NMR, UV, and X-ray analysis with comparisons to geldanamycin, ortho-quino-geldanamycin and a model compound.Entities:
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Year: 2003 PMID： 14535728 DOI： 10.1021/ol035400g
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005