Literature DB >> 19200020

Natural product inhibitors of Hsp90: potential leads for drug discovery.

M W Amolins1, B S J Blagg.   

Abstract

Heat shock protein 90 has emerged as a promising target for the treatment of cancer and neurodegenerative diseases. This review summarizes recent advancements towards the development of natural products as they pertain to the biological and chemical understanding of this molecular chaperone.

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Year:  2009        PMID： 19200020      PMCID： PMC2659174          DOI： 10.2174/138955709787316056

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  152 in total

Review 1.  Role of the heat shock response and molecular chaperones in oncogenesis and cell death.

Authors:  C Jolly; R I Morimoto
Journal:  J Natl Cancer Inst       Date:  2000-10-04       Impact factor: 13.506

Review 2.  Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

Authors:  Yves L Janin
Journal:  J Med Chem       Date:  2005-12-01       Impact factor: 7.446

3.  Putting the heat on cancer.

Authors:  Paul Workman; Emmanuel de Billy
Journal:  Nat Med       Date:  2007-12       Impact factor: 53.440

4.  Designed TPR modules as novel anticancer agents.

Authors:  Aitziber L Cortajarena; Fang Yi; Lynne Regan
Journal:  ACS Chem Biol       Date:  2008-03-20       Impact factor: 5.100

Review 5.  The exploration of macrocycles for drug discovery--an underexploited structural class.

Authors:  Edward M Driggers; Stephen P Hale; Jinbo Lee; Nicholas K Terrett
Journal:  Nat Rev Drug Discov       Date:  2008-07       Impact factor: 84.694

6.  Intratumoral heterogeneity for hsp90beta mRNA levels in a breast cancer cell line.

Authors:  C Luparello; A Noël; I Pucci-Minafra
Journal:  DNA Cell Biol       Date:  1997-10       Impact factor: 3.311

7.  Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.

Authors:  Joseph M Jez; Julian C-H Chen; Giulio Rastelli; Robert M Stroud; Daniel V Santi
Journal:  Chem Biol       Date:  2003-04

8.  Targeting HSP90 to halt neurodegeneration.

Authors:  Kathleen A Gallo
Journal:  Chem Biol       Date:  2006-02

9.  Shared actions of endotoxin and taxol on TNF receptors and TNF release.

Authors:  A H Ding; F Porteu; E Sanchez; C F Nathan
Journal:  Science       Date:  1990-04-20       Impact factor: 47.728

10.  Taxol stabilizes microtubules in mouse fibroblast cells.

Authors:  P B Schiff; S B Horwitz
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205
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  19 in total

Review 1.  A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond.

Authors:  Tony Taldone; Tai Wang; Anna Rodina; Naga Vara Kishore Pillarsetty; Chander S Digwal; Sahil Sharma; Pengrong Yan; Suhasini Joshi; Piyusha P Pagare; Alexander Bolaender; Gail J Roboz; Monica L Guzman; Gabriela Chiosis
Journal:  Cold Spring Harb Perspect Biol       Date:  2020-04-01       Impact factor: 10.005

2.  A systematic protocol for the characterization of Hsp90 modulators.

Authors:  Robert L Matts; Gary E L Brandt; Yuanming Lu; Anshuman Dixit; Mehdi Mollapour; Suiquan Wang; Alison C Donnelly; Leonard Neckers; Gennady Verkhivker; Brian S J Blagg
Journal:  Bioorg Med Chem       Date:  2010-10-19       Impact factor: 3.641

3.  Physiological regulation of Akt activity and stability.

Authors:  Yong Liao; Mien-Chie Hung
Journal:  Am J Transl Res       Date:  2010-01-01       Impact factor: 4.060

Review 4.  HSP90: chaperone-me-not.

Authors:  J M Patki; S S Pawar
Journal:  Pathol Oncol Res       Date:  2013-07-31       Impact factor: 3.201

5.  Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.

Authors:  Huiping Zhao; Alison C Donnelly; Bhaskar R Kusuma; Gary E L Brandt; Douglas Brown; Roger A Rajewski; George Vielhauer; Jeffrey Holzbeierlein; Mark S Cohen; Brian S J Blagg
Journal:  J Med Chem       Date:  2011-05-09       Impact factor: 7.446

6.  Screening of Neem extracts for microbial anti-chaperone activity by employing in vitro enzyme refolding assay.

Authors:  Jyoti M Patki; Priyanka Shah
Journal:  3 Biotech       Date:  2017-08-04       Impact factor: 2.406

7.  HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way.

Authors:  Bin Peng; Limin Xu; Fanfan Cao; Tingxuan Wei; Chunxin Yang; Georges Uzan; Denghai Zhang
Journal:  Mol Cancer       Date:  2010-04-16       Impact factor: 27.401

Review 8.  Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases.

Authors:  Gary E L Brandt; Brian S J Blagg
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

9.  Potent antitrypanosomal activities of heat shock protein 90 inhibitors in vitro and in vivo.

Authors:  Kirsten J Meyer; Theresa A Shapiro
Journal:  J Infect Dis       Date:  2013-04-22       Impact factor: 5.226

10.  Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease.

Authors:  Daniel W Neef; Michelle L Turski; Dennis J Thiele
Journal:  PLoS Biol       Date:  2010-01-19       Impact factor: 8.029
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