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Literature DB >> 16304196

Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter.

Mhairi L Stewart¹, Cyrille Boussard, Reto Brun, Ian H Gilbert, Michael P Barrett.

Abstract

Single benzamidine group-carrying compounds were shown to interact with the Trypanosoma brucei P2 aminopurine transporter. Replacement of the amidine with a guanidine group decreased affinity. Trypanocidal activity was evident, but compounds were equally toxic against trypanosomes lacking the P2 transporter, which indicates additional uptake routes for monobenzamidine-derived compounds.

Entities: Chemical Species

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Year: 2005 PMID： 16304196 PMCID： PMC1315980 DOI： 10.1128/AAC.49.12.5169-5171.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

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Authors: C K Tye; G Kasinathan; M P Barrett; R Brun; V E Doyle; A H Fairlamb; R Weaver; I H Gilbert
Journal: Bioorg Med Chem Lett Date: 1998-04-07 Impact factor: 2.823

2. Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers.

Authors: H Hirumi; K Hirumi
Journal: J Parasitol Date: 1989-12 Impact factor: 1.276

3. A nucleoside transporter from Trypanosoma brucei involved in drug resistance.

Authors: P Mäser; C Sütterlin; A Kralli; R Kaminsky
Journal: Science Date: 1999-07-09 Impact factor: 47.728

4. Adenosine transporters in bloodstream forms of Trypanosoma brucei brucei: substrate recognition motifs and affinity for trypanocidal drugs.

Authors: H P de Koning; S M Jarvis
Journal: Mol Pharmacol Date: 1999-12 Impact factor: 4.436

5. Arsenical-resistant trypanosomes lack an unusual adenosine transporter.

Authors: N S Carter; A H Fairlamb
Journal: Nature Date: 1993-01-14 Impact factor: 49.962

6. The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro.

Authors: B Räz; M Iten; Y Grether-Bühler; R Kaminsky; R Brun
Journal: Acta Trop Date: 1997-11 Impact factor: 3.112

7. Design, synthesis and evaluation of potential inhibitors of HIV gp120-CD4 interactions.

Authors: Cyrille Boussard; Thomas Klimkait; Naheed Mahmood; Martin Pritchard; Ian H Gilbert
Journal: Bioorg Med Chem Lett Date: 2004-05-17 Impact factor: 2.823

8. The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.

Authors: Harry P de Koning; Laura F Anderson; Mhairi Stewart; Richard J S Burchmore; Lynsey J M Wallace; Michael P Barrett
Journal: Antimicrob Agents Chemother Date: 2004-05 Impact factor: 5.191

9. A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity.

Authors: M P Barrett; Z Q Zhang; H Denise; C Giroud; T Baltz
Journal: Mol Biochem Parasitol Date: 1995-07 Impact factor: 1.759

10. Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei.

Authors: N S Carter; B J Berger; A H Fairlamb
Journal: J Biol Chem Date: 1995-11-24 Impact factor: 5.157

4 in total

4. A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.

Authors: Melissa L Sykes; Vicky M Avery
Journal: Parasit Vectors Date: 2009-11-12 Impact factor: 3.876