Literature DB >> 14506056

Activity of human beta-defensin 3 alone or combined with other antimicrobial agents against oral bacteria.

Giuseppantonio Maisetta1, Giovanna Batoni, Semih Esin, Filippo Luperini, Manuela Pardini, Daria Bottai, Walter Florio, Maria Rita Giuca, Mario Gabriele, Mario Campa.   

Abstract

The in vitro activities of human beta-defensin 3 (hBD-3) alone or combined with lysozyme, metronidazole, amoxicillin, and chlorhexidine were investigated with the oral bacteria Streptococcus mutans, Streptococcus sanguinis, Streptococcus sobrinus, Lactobacillus acidophilus, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis. hBD-3 showed bactericidal activity against all of the bacterial species tested. The bactericidal effect was enhanced when the peptide was used in combination with the antimicrobial agents mentioned above.

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Year:  2003        PMID： 14506056      PMCID： PMC201125          DOI： 10.1128/AAC.47.10.3349-3351.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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