Literature DB >> 16436752

In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains.

Giuseppantonio Maisetta1, Giovanna Batoni, Semih Esin, Walter Florio, Daria Bottai, Flavia Favilli, Mario Campa.   

Abstract

The antimicrobial activity of human beta-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.

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Year:  2006        PMID： 16436752      PMCID： PMC1366902          DOI： 10.1128/AAC.50.2.806-809.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

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Authors:  Giuseppantonio Maisetta; Giovanna Batoni; Semih Esin; Filippo Luperini; Manuela Pardini; Daria Bottai; Walter Florio; Maria Rita Giuca; Mario Gabriele; Mario Campa
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  36 in total

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7.  Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines.

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