Literature DB >> 24277031

Contribution of β-lactamases and porin proteins OmpK35 and OmpK36 to carbapenem resistance in clinical isolates of KPC-2-producing Klebsiella pneumoniae.

Ying Zhang1, Xiaofei Jiang, Yanyan Wang, Gang Li, Yueru Tian, Hong Liu, Fuqi Ai, Yiming Ma, Bei Wang, Feiyi Ruan, Kumar Rajakumar.   

Abstract

Fifty-seven carbapenem-resistant Klebsiella pneumoniae isolates belonging to ST11 (50 isolates), ST423 (5 isolates), and two other sequence types were studied. All were positive for blaKPC-2, blaTEM-1, and blaCTX-M-14. SDS-PAGE analysis of six representative isolates demonstrated varied porin expression. Nevertheless, when blaKPC-2 was deleted, carbapenem resistance was markedly reduced. Additionally, SHV-12, DHA-1, and/or VIM-1 appeared to contribute to accessory carbapenemase activity. In contrast, OmpK35 and/or OmpK36 deficiency seemed to serve only as a minor cooperative factor.

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Year:  2013        PMID： 24277031      PMCID： PMC3910872          DOI： 10.1128/AAC.02045-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Relationship between outer membrane alterations and susceptibility to antimicrobial agents in isogenic strains of Klebsiella pneumoniae.

Authors:  S Hernández-Allés; M d Conejo; A Pascual; J M Tomás; V J Benedí; L Martínez-Martínez
Journal:  J Antimicrob Chemother       Date:  2000-08       Impact factor: 5.790

2.  Occurrence and characterization of carbapenemase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program (2000-2004).

Authors:  Lalitagauri M Deshpande; Ronald N Jones; Thomas R Fritsche; Helio S Sader
Journal:  Microb Drug Resist       Date:  2006       Impact factor: 3.431

3.  Outbreaks in distinct regions due to a single Klebsiella pneumoniae clone carrying a bla VIM-1 metallo-{beta}-lactamase gene.

Authors:  Alexandros Ikonomidis; Despina Tokatlidou; Ioulia Kristo; Danai Sofianou; Athanassios Tsakris; Paraskevi Mantzana; Spyros Pournaras; Antonios N Maniatis
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

4.  Susceptibility of Klebsiella pneumoniae isolates from intra-abdominal infections and molecular characterization of ertapenem-resistant isolates.

Authors:  Stephen P Hawser; Samuel K Bouchillon; Christine Lascols; Meredith Hackel; Daryl J Hoban; Robert E Badal; Neil Woodford; David M Livermore
Journal:  Antimicrob Agents Chemother       Date:  2011-06-13       Impact factor: 5.191

5.  Rapid microprocedure for isolating detergent-insoluble outer membrane proteins from Haemophilus species.

Authors:  G M Carlone; M L Thomas; H S Rumschlag; F O Sottnek
Journal:  J Clin Microbiol       Date:  1986-09       Impact factor: 5.948

6.  High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe.

Authors:  Frank M Kaczmarek; Fadia Dib-Hajj; Wenchi Shang; Thomas D Gootz
Journal:  Antimicrob Agents Chemother       Date:  2006-10       Impact factor: 5.191

7.  Paradoxical effect of Klebsiella pneumoniae OmpK36 porin deficiency.

Authors:  Xiuhong Jiang; Bjorn A Espedido; Sally R Partridge; Lee C Thomas; Feng Wang; Jonathan R Iredell
Journal:  Pathology       Date:  2009       Impact factor: 5.306

Review 8.  The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.

Authors:  Patrice Nordmann; Gaelle Cuzon; Thierry Naas
Journal:  Lancet Infect Dis       Date:  2009-04       Impact factor: 25.071

9.  A porin from Klebsiella pneumoniae: sequence homology, three-dimensional model, and complement binding.

Authors:  S Albertí; F Rodríquez-Quiñones; T Schirmer; G Rummel; J M Tomás; J P Rosenbusch; V J Benedí
Journal:  Infect Immun       Date:  1995-03       Impact factor: 3.441

10.  Use of the lambda Red recombinase system to rapidly generate mutants in Pseudomonas aeruginosa.

Authors:  Biliana Lesic; Laurence G Rahme
Journal:  BMC Mol Biol       Date:  2008-02-04       Impact factor: 2.946
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  26 in total

1.  First report of a clinical, multidrug-resistant Enterobacteriaceae isolate coharboring fosfomycin resistance gene fosA3 and carbapenemase gene blaKPC-2 on the same transposon, Tn1721.

Authors:  Gang Li; Ying Zhang; Dexi Bi; Pinghua Shen; Fuqi Ai; Hong Liu; Yueru Tian; Yiming Ma; Bei Wang; Kumar Rajakumar; Hong-Yu Ou; Xiaofei Jiang
Journal:  Antimicrob Agents Chemother       Date:  2014-11-03       Impact factor: 5.191

Review 2.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

3.  Translocation of Carbapenemase Gene blaKPC-2 both Internal and External to Transposons Occurs via Novel Structures of Tn1721 and Exhibits Distinct Movement Patterns.

Authors:  Yu Tang; Gang Li; Wei Liang; Pinghua Shen; Ying Zhang; Xiaofei Jiang
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

Review 4.  Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for the Rapid Detection of Antimicrobial Resistance Mechanisms and Beyond.

Authors:  Marina Oviaño; Germán Bou
Journal:  Clin Microbiol Rev       Date:  2018-11-28       Impact factor: 26.132

5.  Genetic Factors Associated with Enhanced bla KPC Expression in Tn3/Tn4401 Chimeras.

Authors:  Jiansheng Huang; Xiaolei Hu; Yunan Zhao; Yang Shi; Hui Ding; Jianfen Xv; Jianmin Ren; Rongzhen Wu; Zhigang Zhao
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191

6.  Whole-Genome Sequencing Accurately Identifies Resistance to Extended-Spectrum β-Lactams for Major Gram-Negative Bacterial Pathogens.

Authors:  Samuel A Shelburne; Jiwoong Kim; Jose M Munita; Pranoti Sahasrabhojane; Ryan K Shields; Ellen G Press; Xiqi Li; Cesar A Arias; Brandi Cantarel; Ying Jiang; Min S Kim; Samuel L Aitken; David E Greenberg
Journal:  Clin Infect Dis       Date:  2017-09-01       Impact factor: 9.079

7.  Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow More Efficient Diffusion of β-Lactams than Their Escherichia coli Homologs OmpF and OmpC.

Authors:  Etsuko Sugawara; Seiji Kojima; Hiroshi Nikaido
Journal:  J Bacteriol       Date:  2016-11-04       Impact factor: 3.490

8.  Efficacy of humanized high-dose meropenem, cefepime, and levofloxacin against Enterobacteriaceae isolates producing Verona integron-encoded metallo-β-lactamase (VIM) in a murine thigh infection model.

Authors:  Islam M Ghazi; Jared L Crandon; Emil P Lesho; Patrick McGann; David P Nicolau
Journal:  Antimicrob Agents Chemother       Date:  2015-09-28       Impact factor: 5.191

9.  Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

Authors:  Pranita D Tamma; Yunfan Fan; Yehudit Bergman; Geo Pertea; Abida Q Kazmi; Shawna Lewis; Karen C Carroll; Michael C Schatz; Winston Timp; Patricia J Simner
Journal:  Antimicrob Agents Chemother       Date:  2018-12-21       Impact factor: 5.191

10.  Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides.

Authors:  Hua-le Chen; Yan Jiang; Mei-Mei Li; Yao Sun; Jian-Ming Cao; Cui Zhou; Xiao-Xiao Zhang; Yue Qu; Tie-Li Zhou
Journal:  Front Microbiol       Date:  2021-07-02       Impact factor: 5.640
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