Literature DB >> 3531020

Role of capsule and O antigen in resistance of Klebsiella pneumoniae to serum bactericidal activity.

J M Tomás, V J Benedí, B Ciurana, J Jofre.   

Abstract

The ability of Klebsiella pneumoniae strains to resist the bactericidal activity of serum was quantitated. The K. pneumoniae strains tested included mutants lacking the capsular polysaccharide and mutants having a modified lipopolysaccharide structure. The last mutants were obtained as phage-resistant mutants, and their lipopolysaccharide was characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and chemical analysis. Serum-resistant mutants derived from phage-resistant mutants (lipopolysaccharide mutants) were also characterized. Resistance to the bactericidal activity of complement was mediated by the lipopolysaccharide, especially by the O-antigen polysaccharide chains. The capsular polysaccharide seemed not to play any important role in resistance to serum bactericidal activity in this bacterium.

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Year:  1986        PMID： 3531020      PMCID： PMC260120          DOI： 10.1128/iai.54.1.85-89.1986

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  15 in total

1.  Phosphorus assay in column chromatography.

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Journal:  Microbiol Esp       Date:  1968 Jul-Dec

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Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  The complement system in host defense and inflammation.

Authors:  M M Frank
Journal:  Rev Infect Dis       Date:  1979 May-Jun

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Authors:  C M Tsai; C E Frasch
Journal:  Anal Biochem       Date:  1982-01-01       Impact factor: 3.365

Review 6.  Molecular architecture and functioning of the outer membrane of Escherichia coli and other gram-negative bacteria.

Authors:  B Lugtenberg; L Van Alphen
Journal:  Biochim Biophys Acta       Date:  1983-03-21

7.  Solubilization of the cytoplasmic membrane of Escherichia coli by the ionic detergent sodium-lauryl sarcosinate.

Authors:  C Filip; G Fletcher; J L Wulff; C F Earhart
Journal:  J Bacteriol       Date:  1973-09       Impact factor: 3.490

8.  Isolation of the bacteriophage lambda receptor from Escherichia coli.

Authors:  L Randall-Hazelbauer; M Schwartz
Journal:  J Bacteriol       Date:  1973-12       Impact factor: 3.490

9.  Regulation of the OmpA outer membrane protein of Escherichia coli.

Authors:  M G Beher; C A Schnaitman
Journal:  J Bacteriol       Date:  1981-09       Impact factor: 3.490

10.  Protein composition of the outer membrane of Salmonella typhimurium: effect of lipopolysaccharide mutations.

Authors:  G F Ames; E N Spudich; H Nikaido
Journal:  J Bacteriol       Date:  1974-02       Impact factor: 3.490
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  55 in total

1.  Capsular polysaccharide is a major complement resistance factor in lipopolysaccharide O side chain-deficient Klebsiella pneumoniae clinical isolates.

Authors:  D Alvarez; S Merino; J M Tomás; V J Benedí; S Albertí
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

2.  Isolation and characterization of Klebsiella pneumoniae unencapsulated mutants.

Authors:  V J Benedí; B Ciurana; J M Tomás
Journal:  J Clin Microbiol       Date:  1989-01       Impact factor: 5.948

3.  Mechanisms of Klebsiella pneumoniae resistance to complement-mediated killing.

Authors:  S Merino; S Camprubí; S Albertí; V J Benedí; J M Tomás
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

4.  Morphological evidence for penetration of anti-O antibody through the capsule of Klebsiella pneumoniae.

Authors:  Y Meno; K Amako
Journal:  Infect Immun       Date:  1990-05       Impact factor: 3.441

5.  Salicylate-enhanced exposure of Klebsiella pneumoniae subcapsular components.

Authors:  R J Salo; P Domenico; J M Tomás; D C Straus; S Merino; V J Benedí; B A Cunha
Journal:  Infection       Date:  1995 Nov-Dec       Impact factor: 3.553

6.  Vibrio anguillarum resistance to rainbow trout (Oncorhynchus mykiss) serum: role of O-antigen structure of lipopolysaccharide.

Authors:  H T Boesen; K Pedersen; J L Larsen; C Koch; A E Ellis
Journal:  Infect Immun       Date:  1999-01       Impact factor: 3.441

7.  Mesophilic Aeromonas sp. serogroup O:11 resistance to complement-mediated killing.

Authors:  S Merino; X Rubires; A Aguilar; S Albertí; S Hernandez-Allés; V J Benedí; J M Tomas
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

8.  Identification and characterization of antigens as vaccine candidates against Klebsiella pneumoniae.

Authors:  Urban Lundberg; Beatrice M Senn; Wolfgang Schüler; Andreas Meinke; Markus Hanner
Journal:  Hum Vaccin Immunother       Date:  2012-12-18       Impact factor: 3.452

9.  Increased serum resistance in Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases.

Authors:  H Sahly; H Aucken; V J Benedí; C Forestier; V Fussing; D S Hansen; I Ofek; R Podschun; D Sirot; J M Tomás; D Sandvang; U Ullmann
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

10.  Impairment of respiratory burst in polymorphonuclear leukocytes by extended-spectrum beta-lactamase-producing strains of Klebsiella pneumoniae.

Authors:  H Sahly; H Aucken; V J Benedi; C Forestier; V Fussing; D S Hansen; I Ofek; R Podschun; D Sirot; D Sandvang; J M Tomás; U Ullmann
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2003-12-02       Impact factor: 3.267
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