Literature DB >> 14504235

Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene.

Carine Nezer1, Catherine Collette, Laurence Moreau, Benoît Brouwers, Jong-Joo Kim, Elisabetta Giuffra, Nadine Buys, Leif Andersson, Michel Georges.   

Abstract

We herein describe the fine mapping of an imprinted QTL with major effect on muscle mass that was previously assigned to distal SSC2p in the pig. The proposed approach exploits linkage disequilibrium in combination with QTL genotyping by marker-assisted segregation analysis. By identifying a haplotype shared by all "Q" chromosomes, we map the QTL to an approximately 250-kb chromosome segment containing INS and IGF2 as the only known paternally expressed genes. This considerably reinforces the candidacy of these genes, justifying their detailed analysis.

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Year:  2003        PMID： 14504235      PMCID： PMC1462731     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  24 in total

1.  A porcine BAC library with tenfold genome coverage: a resource for physical and genetic map integration.

Authors:  S C Fahrenkrug; G A Rohrer; B A Freking; T P Smith; K Osoegawa; C L Shu; J J Catanese; P J de Jong
Journal:  Mamm Genome       Date:  2001-06       Impact factor: 2.957

Review 2.  Finding the molecular basis of quantitative traits: successes and pitfalls.

Authors:  J Flint; R Mott
Journal:  Nat Rev Genet       Date:  2001-06       Impact factor: 53.242

3.  Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.

Authors:  Maria Smit; Karin Segers; Laura Garcia Carrascosa; Tracy Shay; Francesca Baraldi; Gabor Gyapay; Gary Snowder; Michel Georges; Noelle Cockett; Carole Charlier
Journal:  Genetics       Date:  2003-01       Impact factor: 4.562

4.  Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition.

Authors:  Sarah Blott; Jong-Joo Kim; Sirja Moisio; Anne Schmidt-Küntzel; Anne Cornet; Paulette Berzi; Nadine Cambisano; Christine Ford; Bernard Grisart; Dave Johnson; Latifa Karim; Patricia Simon; Russell Snell; Richard Spelman; Jerry Wong; Johanna Vilkki; Michel Georges; Frédéric Farnir; Wouter Coppieters
Journal:  Genetics       Date:  2003-01       Impact factor: 4.562

5.  Detecting recent positive selection in the human genome from haplotype structure.

Authors:  Pardis C Sabeti; David E Reich; John M Higgins; Haninah Z P Levine; Daniel J Richter; Stephen F Schaffner; Stacey B Gabriel; Jill V Platko; Nick J Patterson; Gavin J McDonald; Hans C Ackerman; Sarah J Campbell; David Altshuler; Richard Cooper; Dominic Kwiatkowski; Ryk Ward; Eric S Lander
Journal:  Nature       Date:  2002-10-09       Impact factor: 49.962

6.  Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition.

Authors:  Bernard Grisart; Wouter Coppieters; Frédéric Farnir; Latifa Karim; Christine Ford; Paulette Berzi; Nadine Cambisano; Myriam Mni; Suzanne Reid; Patricia Simon; Richard Spelman; Michel Georges; Russell Snell
Journal:  Genome Res       Date:  2002-02       Impact factor: 9.043

7.  A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci.

Authors:  J D Terwilliger
Journal:  Am J Hum Genet       Date:  1995-03       Impact factor: 11.025

Review 8.  Patterns of linkage disequilibrium in the human genome.

Authors:  Kristin G Ardlie; Leonid Kruglyak; Mark Seielstad
Journal:  Nat Rev Genet       Date:  2002-04       Impact factor: 53.242

9.  Results of a whole genome scan targeting QTL for growth and carcass traits in a Piétrain x Large White intercross.

Authors:  Carine Nezer; Laurence Moreau; Danny Wagenaar; Michel Georges
Journal:  Genet Sel Evol       Date:  2002 May-Jun       Impact factor: 4.297

10.  Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs.

Authors:  Valérie Amarger; Minh Nguyen; Anne-Sophie Van Laere; Martin Braunschweig; Carine Nezer; Michel Georges; Leif Andersson
Journal:  Mamm Genome       Date:  2002-07       Impact factor: 2.957
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  20 in total

Review 1.  Effects of genomic imprinting on quantitative traits.

Authors:  Hamish G Spencer
Journal:  Genetica       Date:  2008-08-09       Impact factor: 1.082

2.  Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature.

Authors:  Latifa Karim; Haruko Takeda; Li Lin; Tom Druet; Juan A C Arias; Denis Baurain; Nadine Cambisano; Stephen R Davis; Frédéric Farnir; Bernard Grisart; Bevin L Harris; Mike D Keehan; Mathew D Littlejohn; Richard J Spelman; Michel Georges; Wouter Coppieters
Journal:  Nat Genet       Date:  2011-04-24       Impact factor: 38.330

3.  Genome-wide study refines the quantitative trait locus for number of ribs in a Large White × Minzhu intercross pig population and reveals a new candidate gene.

Authors:  Long-Chao Zhang; Jing-Wei Yue; Lei Pu; Li-Gang Wang; Xin Liu; Jing Liang; Hua Yan; Ke-Bin Zhao; Na Li; Hui-Bi Shi; Yue-Bo Zhang; Li-Xian Wang
Journal:  Mol Genet Genomics       Date:  2016-06-15       Impact factor: 3.291

Review 4.  Lack of exercise is a major cause of chronic diseases.

Authors:  Frank W Booth; Christian K Roberts; Matthew J Laye
Journal:  Compr Physiol       Date:  2012-04       Impact factor: 9.090

5.  Genome-wide association studies of hypertension: light at the end of the tunnel.

Authors:  Claire E Hastie; Sandosh Padmanabhan; Anna F Dominiczak
Journal:  Int J Hypertens       Date:  2010-04-29       Impact factor: 2.420

6.  Fine-scale analysis of parasite resistance genes in the red flour beetle, Tribolium castaneum.

Authors:  Daibin Zhong; Aditi Pai; Mei-Hui Wang; Naomi Keech; Guiyun Yan
Journal:  Genetics       Date:  2013-06-14       Impact factor: 4.562

7.  Fine mapping of quantitative trait loci affecting female fertility in dairy cattle on BTA03 using a dense single-nucleotide polymorphism map.

Authors:  Tom Druet; Sébastien Fritz; Mekki Boussaha; Slim Ben-Jemaa; François Guillaume; David Derbala; Diana Zelenika; Doris Lechner; Céline Charon; Didier Boichard; Ivo G Gut; André Eggen; Mathieu Gautier
Journal:  Genetics       Date:  2008-04       Impact factor: 4.562

8.  Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data.

Authors:  Sheron Wen; Chenguang Wang; Arthur Berg; Yao Li; Myron M Chang; Roger B Fillingim; Margaret R Wallace; Roland Staud; Lee Kaplan; Rongling Wu
Journal:  Algorithms Mol Biol       Date:  2009-08-11       Impact factor: 1.405

Review 9.  Genomic imprinting and parent-of-origin effects on complex traits.

Authors:  Heather A Lawson; James M Cheverud; Jason B Wolf
Journal:  Nat Rev Genet       Date:  2013-08-06       Impact factor: 53.242

10.  A further look at porcine chromosome 7 reveals VRTN variants associated with vertebral number in Chinese and Western pigs.

Authors:  Yin Fan; Yuyun Xing; Zhiyan Zhang; Huashui Ai; Zixuan Ouyang; Jing Ouyang; Ming Yang; Pinghua Li; Yijie Chen; Jun Gao; Lin Li; Lusheng Huang; Jun Ren
Journal:  PLoS One       Date:  2013-04-24       Impact factor: 3.240
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