Literature DB >> 1438294

Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast.

R T Lee1, C L Peterson, A F Calman, I Herskowitz, J J O'Donnell.   

Abstract

A human cDNA encoding a galactokinase (EC 2.7.1.6) was isolated by complementation of a galactokinase-deficient (gal1-) strain of Saccharomyces cerevisiae. This cDNA encodes a predicted protein of 458 amino acids with 29% identity to galactokinase of Saccharomyces carlsbergensis. Previous studies have mapped a human galactokinase gene (GK1) to chromosome 17q23-25, closely linked to thymidine kinase. The galactokinase gene that we have isolated (GK2) is located on chromosome 15. The relationship between the disease locus for galactokinase deficiency galactosemia, which is responsible for cataracts in newborns and possibly presenile cataracts in adults, and the two galactokinase loci is unknown.

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Year:  1992        PMID： 1438294      PMCID： PMC50447          DOI： 10.1073/pnas.89.22.10887

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  39 in total

1.  PCR primers for human chromosomes: reagents for the rapid analysis of somatic cell hybrids.

Authors:  S Theune; J Fung; S Todd; A Y Sakaguchi; S L Naylor
Journal:  Genomics       Date:  1991-03       Impact factor: 5.736

Review 2.  The P-loop--a common motif in ATP- and GTP-binding proteins.

Authors:  M Saraste; P R Sibbald; A Wittinghofer
Journal:  Trends Biochem Sci       Date:  1990-11       Impact factor: 13.807

3.  The organization and transcription of the galactose gene cluster of Saccharomyces.

Authors:  T P St John; R W Davis
Journal:  J Mol Biol       Date:  1981-10-25       Impact factor: 5.469

4.  Galactose utilization in Lactobacillus helveticus: isolation and characterization of the galactokinase (galK) and galactose-1-phosphate uridyl transferase (galT) genes.

Authors:  B Mollet; N Pilloud
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

5.  Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

Authors:  D Schild; A J Brake; M C Kiefer; D Young; P J Barr
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

6.  Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.

Authors:  J Colicelli; C Nicolette; C Birchmeier; L Rodgers; M Riggs; M Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

7.  Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae.

Authors:  J Meyer; A Walker-Jonah; C P Hollenberg
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

8.  Newborn screening for galactosemia and other galactose metabolic defects.

Authors:  H L Levy; G Hammersen
Journal:  J Pediatr       Date:  1978-06       Impact factor: 4.406

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance.

Authors:  J D Boeke; F LaCroute; G R Fink
Journal:  Mol Gen Genet       Date:  1984
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  5 in total

1.  Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.

Authors:  Gil-Soo Han; Avula Sreenivas; Mal-Gi Choi; Yu-Fang Chang; Shelley S Martin; Enoch P Baldwin; George M Carman
Journal:  J Biol Chem       Date:  2005-09-22       Impact factor: 5.157

2.  The arabinose kinase, ARA1, gene of Arabidopsis is a novel member of the galactose kinase gene family.

Authors:  S Sherson; I Gy; J Medd; R Schmidt; C Dean; M Kreis; A Lecharny; C Cobbett
Journal:  Plant Mol Biol       Date:  1999-03       Impact factor: 4.076

3.  A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes.

Authors:  W D Kruger; D R Cox
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-05       Impact factor: 11.205

4.  Phosphorylation of CTP synthetase from Saccharomyces cerevisiae by protein kinase C.

Authors:  W L Yang; G M Carman
Journal:  J Biol Chem       Date:  1995-06-23       Impact factor: 5.157

Review 5.  Regulation of galactose-1-phosphate uridyltransferase gene expression.

Authors:  R A Heidenreich
Journal:  Eur J Pediatr       Date:  1995       Impact factor: 3.183
  5 in total

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