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Literature DB >> 14342515

METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE BY RAT-LIVER HOMOGENATES.

Abstract

1. The main products of the metabolism of 7,12-dimethylbenz[a]anthracene by rat-liver homogenates are the isomeric monohydroxymethyl derivatives. The syntheses of these compounds are described. 2. Two phenolic products and two dihydrodihydroxy compounds were formed, but none of these appeared to have been formed by hydroxylation at the ;K region'. There was little evidence for the formation of a glutathione conjugate of the hydrocarbon. 3. The monohydroxymethyl derivatives are products of the hydroxylation of the hydrocarbon in the ascorbic acid-Fe(2+)-oxygen model hydroxylating system.

Entities: Chemical Species

Keywords: BENZANTHRACENES; CHEMISTRY, ANALYTICAL; CHROMATOGRAPHY; EXPERIMENTAL LAB STUDY; HOMOGENATES; LIVER FUNCTION; METABOLISM; RATS

Mesh：

Substances：

Year: 1965 PMID： 14342515 PMCID： PMC1206806 DOI： 10.1042/bj0950780

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

6 in total

1. Side chain oxidation of alkyl substituted ring compounds. I. Enzymatic oxidation of p-nitrotoluene.

Authors: J R GILLETTE
Journal: J Biol Chem Date: 1959-01 Impact factor: 5.157

2. Ascorbic acid in aromatic hydroxylation. I. A model system for aromatic hydroxylation.

Authors: S UDENFRIEND; C T CLARK; J AXELROD; B B BRODIE
Journal: J Biol Chem Date: 1954-06 Impact factor: 5.157

3. An enzyme from rat liver catalysing conjugations with glutathione.

Authors: J Booth; E Boyland; P Sims
Journal: Biochem J Date: 1961-06 Impact factor: 3.857

4. Metabolism of polycyclic compounds. 24. The metabolism of benz[alpha]anthracene.

Authors: E Boyland; P Sims
Journal: Biochem J Date: 1964-06 Impact factor: 3.857

5. Metabolism of polycyclic compounds. 25. The metabolism of anthracene and some related compounds in rats.

Authors: P Sims
Journal: Biochem J Date: 1964-09 Impact factor: 3.857

6. Metabolism of polycyclic compounds. 26. The hydroxylation of some aromatic hydrocarbons by the ascorbic acid model hydroxylating system and by rat-liver microsomes.

Authors: E Boyland; M Kumura; P Sims
Journal: Biochem J Date: 1964-09 Impact factor: 3.857

6 in total

23 in total

1. A bacteriophage system for screening and study of biologically active polycyclic aromatic hydrocarbons and related compounds.

Authors: W T Hsu; R G Harvey; E J Lin; S B Weiss
Journal: Proc Natl Acad Sci U S A Date: 1977-04 Impact factor: 11.205

2. [Experimental studies of the retention, distribution and metabolism of carcinogenic hydrocarbones in the respiratory organs of the Syrian golden hamster].

Authors: W Dontenwill; H Elmenhorst; G Reckzeh; H P Harke; L Stadler
Journal: Z Krebsforsch Date: 1968

3. The metabolism of 7,12-dimethylbenz (a) anthracene by homogenates of the stomach and small intestine of mice.

Authors: A Gentil; P Sims
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1971

4. Effect of metopirone and 3-(1,2,3,4-tetrahydro-1-oxo-2-naphthyl)-pyridine on the metabolism of corticosteroids and DMBA in relation to adrenal necrosis.

Authors: P H Jellinck; M Garland; D McRitchie
Journal: Experientia Date: 1968-02-15

9. The effect of pretreatment with adrenal-protecting compounds on the metabolism of 7,12-dimethylbenz[a]anthracene and related compounds by rat-liver homogenates.

Authors: E Boyland; P Sims
Journal: Biochem J Date: 1967-08 Impact factor: 3.857

10. Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to 7,12-dimethylbenz(a)anthracene.

Authors: P Sims
Journal: Biochem J Date: 1973-02 Impact factor: 3.857