Literature DB >> 5256999

Selective destruction of adrenal cortex by pulse doses of derivatives of 12-methylbenz(a)anthracene.

C Huggins, S Morii, J Pataki.   

Abstract

Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.

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Year:  1969        PMID： 5256999      PMCID： PMC223655          DOI： 10.1073/pnas.62.3.704

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  AROMATIC AZO DERIVATIVES PREVENTING MAMMARY CANCER AND ADRENAL INJURY FROM 7,12-DIMETHYLBENZ(A)ANTHRACENE.

Authors:  C HUGGINS; J PATAKI
Journal:  Proc Natl Acad Sci U S A       Date:  1965-04       Impact factor: 11.205

2.  Massive adrenal necrosis in rats caused by 9,10-dimethyl-1,2-benzanthracene and its inhibition by metyrapone.

Authors:  A R CURRIE; J E HELFENSTEIN; S YOUNG
Journal:  Lancet       Date:  1962-12-08       Impact factor: 79.321

3.  Organ lesions produced by hexadimethrine and their modification by various agents.

Authors:  H SELYE; G CABBIANI; B TUCHWEBER
Journal:  Med Exp Int J Exp Med       Date:  1963

4.  Composition and preparation of experimental intravenous fat emulsions.

Authors:  P E Schurr
Journal:  Cancer Res       Date:  1969-01       Impact factor: 12.701

5.  Production and prevention of two distinctive kinds of destruction of adrenal cortex.

Authors:  C B Huggins; T Sugiyama
Journal:  Nature       Date:  1965-06-26       Impact factor: 49.962

6.  Adrenal destruction and cancer induced by hydroxyalkyl derivatives of 7,12-dimethylbenz(a)anthracene.

Authors:  J Pataki; C B Huggins
Journal:  Biochem Pharmacol       Date:  1967-04       Impact factor: 5.858

7.  INHIBITORY EFFECT OF POLYNUCLEAR HYDROCARBONS AND AMPHENONE ANALOGS ON INDUCTION OF ACUTE ADRENAL NECROSIS BY 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE.

Authors:  T L DAO; Y TANAKA
Journal:  Cancer Res       Date:  1963-09       Impact factor: 12.701

8.  METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE BY RAT-LIVER HOMOGENATES.

Authors:  E BOYLAND; P SIMS
Journal:  Biochem J       Date:  1965-06       Impact factor: 3.857

9.  Selective adrenal necrosis and apoplexy induced by 7, 12-dimethylbenz(a)anthracene.

Authors:  C HUGGINS; S MORII
Journal:  J Exp Med       Date:  1961-11-01       Impact factor: 14.307
  9 in total
  3 in total

1.  Azo dyes prevent hydrocarbon-induced leukemia in the rat.

Authors:  C B Huggins; N Ueda; A Russo
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  Cytogenetic studies of leukemia induced by 6,8,12-and 7,8,12-trimethylbenz(a)anthracene.

Authors:  T Sugiyama; F P Brillantes
Journal:  J Exp Med       Date:  1970-02       Impact factor: 14.307

3.  Hundred day leukemia: preferential induction in rat by pulse-doses of 7,8,12-trimethylbenz(a)anthracene.

Authors:  C Huggins; L Grand; H Oka
Journal:  J Exp Med       Date:  1970-02       Impact factor: 14.307
  3 in total

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