Literature DB >> 5288372

Molecular characteristics of some carcinogenic hydrocarbons.

E Cavalieri, M Calvin.   

Abstract

The chemical reactivity and presumably the carcinogenic activity induced in aromatic hydrocarbons by hydroxylating enzymes may be due to the generation of electrophilic centers in some (benzo[a]pyrene) or nucleophilic centers in others (7,12-dimethylbenz[a]anthracene or 3-methylcholanthrene). These centers, which are at positions complementary to the points of activation by acid-derived protons (models of the positive oxygen of the hydroxylating enzymes), may react simultaneously with corresponding cellular components.

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Year:  1971        PMID： 5288372      PMCID： PMC389165          DOI： 10.1073/pnas.68.6.1251

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  EVIDENCE FOR THE BINDING OF POLYNUCLEAR AROMATIC HYDROCARBONS TO THE NUCLEIC ACIDS OF MOUSE SKIN: RELATION BETWEEN CARCINOGENIC POWER OF HYDROCARBONS AND THEIR BINDING TO DEOXYRIBONUCLEIC ACID.

Authors:  P BROOKES; P D LAWLEY
Journal:  Nature       Date:  1964-05-23       Impact factor: 49.962

2.  The metabolism of isolated rat-liver nuclei.

Authors:  K R REES; G F ROWLAND
Journal:  Biochem J       Date:  1961-01       Impact factor: 3.857

3.  Electronic structure and carcinogenic activity of aromatic molecules; new developments.

Authors:  A PULLMAN; B PULLMAN
Journal:  Adv Cancer Res       Date:  1955       Impact factor: 6.242

4.  Nuclear electron transport. I. Electron transport enzymes in bovine liver nuclei and nuclear membrane.

Authors:  R Berezney; L K Funk; F L Crane
Journal:  Biochem Biophys Res Commun       Date:  1970-01-06       Impact factor: 3.575

Review 5.  Studies on the cellular and molecular mechanisms of hydrocarbon carcinogenesis.

Authors:  C Heidelberger
Journal:  Eur J Cancer       Date:  1970-06       Impact factor: 9.162

6.  Isolation and degradation of DNA from cells treated with tritium-labeled 7,12-dimethylbenz(a)anthracene: studies on the nature of the binding of this carcinogen to DNA.

Authors:  P Brookes; C Heidelberger
Journal:  Cancer Res       Date:  1969-01       Impact factor: 12.701

7.  The metabolism of some aromatic hydrocarbons by mouse embryo cell cultures.

Authors:  P Sims
Journal:  Biochem Pharmacol       Date:  1970-01       Impact factor: 5.858

8.  The metabolism of 3-methylcholanthrene and some related compounds by rat-liver homogenates.

Authors:  P Sims
Journal:  Biochem J       Date:  1966-01       Impact factor: 3.857

9.  METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE BY RAT-LIVER HOMOGENATES.

Authors:  E BOYLAND; P SIMS
Journal:  Biochem J       Date:  1965-06       Impact factor: 3.857

10.  Oncogenes of RNA tumor viruses as determinants of cancer.

Authors:  R J Huebner; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1969-11       Impact factor: 11.205
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  8 in total

Review 1.  The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.

Authors:  Ercole Cavalieri; Eleanor Rogan
Journal:  Mol Aspects Med       Date:  2013-08-30

2.  Specific positions involved in enzyme catalyzed covalent binding of benzo[a]pyrene to poly(G).

Authors:  T Meehan; D Warshawsky; M Calvin
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

3.  Photoelectron microscopy: a new approach to mapping organic and biological surfaces.

Authors:  O H Griffith; G H Lesch; G F Rempfer; G B Birrell; C A Burke; D W Schlosser; M H Mallon; G B Lee; R G Stafford; P C Jost; T B Marriott
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205

Review 4.  Carcinogenesis.

Authors:  M Calvin
Journal:  Naturwissenschaften       Date:  1975-09

5.  Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding.

Authors:  N Kinoshita; H V Gelboin
Journal:  Proc Natl Acad Sci U S A       Date:  1972-04       Impact factor: 11.205

6.  Contrast in the photoelectric effect of organic and biochemical surfaces. A first step towards selective labeling in photoelectron microscopy.

Authors:  G B Birrell; C Burke; P Dehlinger; O H Griffith
Journal:  Biophys J       Date:  1973-05       Impact factor: 4.033

7.  Carcinogenic activation of benzo(a)pyrene by iodine and ferric chloride in the respiratory tract of Syrian golden hamsters.

Authors:  F Stenbäck; J Rowland
Journal:  Experientia       Date:  1978-08-15

8.  Mutagenic and carcinogenic properties of polycyclic aromatic hydrocarbons.

Authors:  Y V Pashin; L M Bakhitova
Journal:  Environ Health Perspect       Date:  1979-06       Impact factor: 9.031
  8 in total

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