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Literature DB >> 1391472

PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model.

K Nho¹, D Glower, S Bredehoeft, H Shankar, R Shorr, A Abuchowski.

Abstract

An initial evaluation of PEG-bHb was performed using a modified hypovolemic shock model. PEG-bHb had a substantially longer intravascular half-life than native Hb and no measurable hemoglobinuria was observed in the canine. PEG-bHb allowed successful resuscitation with an oxygen carrying capacity of 14-22% over that of lactated Ringer's solution.

Entities: Chemical Disease Species

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Year: 1992 PMID： 1391472 DOI： 10.3109/10731199209119677

Source DB: PubMed Journal: Biomater Artif Cells Immobilization Biotechnol ISSN： 1055-7172

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Cited

11 in total

1. Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion.

Authors: Judith A Klaus; Kathleen K Kibler; Abraham Abuchowski; Raymond C Koehler
Journal: Artif Cells Blood Substit Immobil Biotechnol Date: 2010-10

2. Effects of recombinant human hemoglobin on opossum sphincter of Oddi motor function in vivo and in vitro.

Authors: J J Cullen; J L Conklin; J Murray; A Ledlow; G Rosenthal
Journal: Dig Dis Sci Date: 1996-02 Impact factor: 3.199

Review 3. Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids.

Authors: Pedro Cabrales; Marcos Intaglietta
Journal: ASAIO J Date: 2013 Jul-Aug Impact factor: 2.872

Review 4. Oxidative pathways in the sickle cell and beyond.

Authors: Abdu I Alayash
Journal: Blood Cells Mol Dis Date: 2017-05-20 Impact factor: 3.039

5. Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia.

Authors: Jian Zhang; Suyi Cao; Herman Kwansa; Daina Crafa; Kathleen K Kibler; Raymond C Koehler
Journal: J Appl Physiol (1985) Date: 2012-10-04

6. PEGylation of αα-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG αα-Hbs.

Authors: Fantao Meng; Amy G Tsai; Marcos Intaglietta; Seetharama A Acharya
Journal: Artif Cells Nanomed Biotechnol Date: 2014-03-06 Impact factor: 5.678

PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model.

1. Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion.

2. Effects of recombinant human hemoglobin on opossum sphincter of Oddi motor function in vivo and in vitro.

Review 3. Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids.

Review 4. Oxidative pathways in the sickle cell and beyond.

5. Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia.

6. PEGylation of αα-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG αα-Hbs.

Review 7. Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?

Review 8. Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers.

Review 9. Nanomedicines: A Potential Treatment for Blood Disorder Diseases.

10. Mechanisms of Toxicity and Modulation of Hemoglobin-based Oxygen Carriers.