Literature DB >> 20486873

Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion.

Judith A Klaus1, Kathleen K Kibler, Abraham Abuchowski, Raymond C Koehler.   

Abstract

The effect of transfusion of PEGylated hemoglobin (PEG-Hb) was evaluated in anesthetized rats subjected to 2 hours of focal cerebral ischemia and 1 day of reperfusion. PEG-Hb was stored in the carboxy state (PEG-COHb) to reduce autooxidation and increase the shelf life. Transfusion of 10 ml/kg of PEG-COHb at 20 minutes of ischemia did not alter arterial blood pressure or increase red cell flux in the ischemic core. Plasma hemoglobin increased to only 0.6 g/dL, yet infarct volume was markedly decreased and neurological deficits were improved. We conclude that early topload transfusion of PEG-COHb protects the brain from ischemic stroke.

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Year:  2010        PMID： 20486873      PMCID： PMC3121099          DOI： 10.3109/10731199.2010.488635

Source DB:  PubMed          Journal:  Artif Cells Blood Substit Immobil Biotechnol        ISSN： 1073-1199


  25 in total

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5.  Cerebral O2 transport with hematocrit reduced by cross-linked hemoglobin transfusion.

Authors:  J A Ulatowski; E Bucci; T Nishikawa; A Razynska; M A Williams; R Takeshima; R J Traystman; R C Koehler
Journal:  Am J Physiol       Date:  1996-02

6.  The effects of hemodilution with polyethylene glycol bovine hemoglobin (PEG-Hb) in a conscious porcine model.

Authors:  C D Conover; P Malatesta; L Lejeune; C L Chang; R G Shorr
Journal:  J Investig Med       Date:  1996-06       Impact factor: 2.895

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8.  S-nitrosylated pegylated hemoglobin reduces the size of cerebral infarction in rats.

Authors:  Akira T Kawaguchi; Kunihiko Nakai; Dai Fukumoto; Mariko Yamano; Munetaka Haida; Hideo Tsukada
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10.  Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters.

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Review 5.  The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises.

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6.  Scalable production and complete biophysical characterization of poly(ethylene glycol) surface conjugated liposome encapsulated hemoglobin (PEG-LEH).

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7.  Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia.

Authors:  Jian Zhang; Suyi Cao; Herman Kwansa; Daina Crafa; Kathleen K Kibler; Raymond C Koehler
Journal:  J Appl Physiol (1985)       Date:  2012-10-04

8.  Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1α and mitochondrial respiration.

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9.  Method parameters' impact on mortality and variability in rat stroke experiments: a meta-analysis.

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