Literature DB >> 3023521

A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.

V Radoux, P P Chen, J A Sorge, D A Carson.   

Abstract

The full-length gene that encodes the light chain variable regions of an idiotypically related group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The deduced amino acid sequence is identical to four separate RF proteins. These results prove that genes capable of encoding human anti-IgG autoantibody light chains without any somatic mutation are present in the kappa gene repertoire of normal people.

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Year:  1986        PMID： 3023521      PMCID： PMC2188481          DOI： 10.1084/jem.164.6.2119

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

1.  Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgM kappa with anti-gamma-globulin activity.

Authors:  F Goñi; P P Chen; B Pons-Estel; D A Carson; B Frangione
Journal:  J Immunol       Date:  1985-12       Impact factor: 5.422

2.  Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults.

Authors:  S Fong; P P Chen; T A Gilbertson; J R Weber; R I Fox; D A Carson
Journal:  J Immunol       Date:  1986-07-01       Impact factor: 5.422

3.  Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines.

Authors:  G D Yancopoulos; S V Desiderio; M Paskind; J F Kearney; D Baltimore; F W Alt
Journal:  Nature       Date:  1984 Oct 25-31       Impact factor: 49.962

4.  Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.

Authors:  B Diamond; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

5.  New M13 vectors for cloning.

Authors:  J Messing
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

6.  Lambda replacement vectors carrying polylinker sequences.

Authors:  A M Frischauf; H Lehrach; A Poustka; N Murray
Journal:  J Mol Biol       Date:  1983-11-15       Impact factor: 5.469

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity.

Authors:  H G Kunkel; V Agnello; F G Joslin; R J Winchester; J D Capra
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307

9.  A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

Authors:  Y Naparstek; J André-Schwartz; T Manser; L J Wysocki; L Breitman; B D Stollar; M Gefter; R S Schwartz
Journal:  J Exp Med       Date:  1986-08-01       Impact factor: 14.307

10.  Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides.

Authors:  P P Chen; F Gõni; R A Houghten; S Fong; R Goldfien; J H Vaughan; B Frangione; D A Carson
Journal:  J Exp Med       Date:  1985-08-01       Impact factor: 14.307
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  49 in total

1.  Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody.

Authors:  W A Marasco; J Bagley; C Zani; M Posner; L Cavacini; W A Haseltine; J Sodroski
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

2.  Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypes.

Authors:  T J Kipps; S F Duffy
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

3.  Evidence that the V kappa III gene usage is nonstochastic in both adult and newborn peripheral B cells and that peripheral CD5+ adult B cells are oligoclonal.

Authors:  J C Weber; G Blaison; T Martin; A M Knapp; J L Pasquali
Journal:  J Clin Invest       Date:  1994-05       Impact factor: 14.808

Review 4.  Idiotypes and anti-idiotypes: what are they trying to tell us?

Authors:  R A Watts; D A Isenberg
Journal:  Ann Rheum Dis       Date:  1988-09       Impact factor: 19.103

Review 5.  Rheumatoid factor cross idiotypes.

Authors:  V Agnello
Journal:  Springer Semin Immunopathol       Date:  1988

Review 6.  Cross-reacting idiotypes on cryoprecipitating rheumatoid factor.

Authors:  P P Chen; S Fong; F Goni; G J Silverman; R I Fox; M F Liu; B Frangione; D A Carson
Journal:  Springer Semin Immunopathol       Date:  1988

7.  Control of autoantibody affinity by selection against amino acid replacements in the complementarity-determining regions.

Authors:  M Børretzen; I Randen; E Zdárský; O Førre; J B Natvig; K M Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

8.  Rheumatoid factors induce signaling from B cells, leading to Epstein-Barr virus and B-cell activation.

Authors:  Lixin Yang; Masayuki Hakoda; Kazuya Iwabuchi; Tsuyoshi Takeda; Takao Koike; Naoyuki Kamatani; Kenzo Takada
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

9.  Molecular mechanisms resulting in pathogenic anti-mouse erythrocyte antibodies in New Zealand black mice.

Authors:  B B Scott; S Sadigh; M Stow; R A Mageed; E M Andrew; R N Maini
Journal:  Clin Exp Immunol       Date:  1993-07       Impact factor: 4.330

10.  Recombinant monoclonal thyrotropin-stimulation blocking antibody (TSBAb) established from peripheral lymphocytes of a hypothyroid patient with primary myxedema.

Authors:  K Moriyama; J Okuda; M Saijo; Y Hattori; N Kanamoto; Y Hataya; F Matsuda; T Mori; K Nakao; T Akamizu
Journal:  J Endocrinol Invest       Date:  2003-11       Impact factor: 4.256
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