Literature DB >> 2717946

Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity.

N Zein1, M Poncin, R Nilakantan, G A Ellestad.   

Abstract

Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2717946     DOI： 10.1126/science.2717946

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  32 in total

1.  A continuous assay for DNA cleavage: the application of "break lights" to enediynes, iron-dependent agents, and nucleases.

Authors:  J B Biggins; J R Prudent; D J Marshall; M Ruppen; J S Thorson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

2.  Molecular models of neocarzinostatin damage of DNA: analysis of sequence dependence in 5'GAGCG:5'CGCTC.

Authors:  A Galat; I H Goldberg
Journal:  Nucleic Acids Res       Date:  1990-04-25       Impact factor: 16.971

3.  Simultaneous determination of helical unwinding angles and intrinsic association constants in ligand-DNA complexes: the interaction between DNA and calichearubicin B.

Authors:  S M Zeman; K M Depew; S J Danishefsky; D M Crothers
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-14       Impact factor: 11.205

4.  Cleavage behavior of calicheamicin gamma 1 and calicheamicin T.

Authors:  S Walker; R Landovitz; W D Ding; G A Ellestad; D Kahne
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

5.  Calicheamicin-DNA complexes: warhead alignment and saccharide recognition of the minor groove.

Authors:  N Ikemoto; R A Kumar; T T Ling; G A Ellestad; S J Danishefsky; D J Patel
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

6.  Structural characterization of CalO2: a putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway.

Authors:  Jason G McCoy; Heather D Johnson; Shanteri Singh; Craig A Bingman; In-Kyoung Lei; Jon S Thorson; George N Phillips
Journal:  Proteins       Date:  2009-01

7.  Characterization of CalE10, the N-oxidase involved in calicheamicin hydroxyaminosugar formation.

Authors:  Heather D Johnson; Jon S Thorson
Journal:  J Am Chem Soc       Date:  2008-12-31       Impact factor: 15.419

8.  Selective proteolytic activity of the antitumor agent kedarcidin.

Authors:  N Zein; A M Casazza; T W Doyle; J E Leet; D R Schroeder; W Solomon; S G Nadler
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

9.  The carbohydrate domain of calicheamicin gamma I1 determines its sequence specificity for DNA cleavage.

Authors:  J Drak; N Iwasawa; S Danishefsky; D M Crothers
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

10.  Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner.

Authors:  N Zein; K L Colson; J E Leet; D R Schroeder; W Solomon; T W Doyle; A M Casazza
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.