Literature DB >> 1358062

Modulation in vivo of beta-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16-8714.

J P Revelli1, P Muzzin, J P Giacobino.   

Abstract

The number of beta 3-adrenergic receptors (AR) in plasma membranes from interscapular brown adipose tissue (IBAT) was decreased by 62% in lean Zucker rats treated with the thermogenic beta-adrenergic agonist Ro 16-8714 as compared with controls after 72 h of treatment. The loss of beta 3-AR number was preceded by a 93% decrease in the steady-state level of beta 3-AR mRNA at 30 h. Similar results were obtained in obese (fa/fa) Zucker rats. Ro 16-8714 had no effect on the number of beta 1- and beta 2-ARs in IBAT. This is the first report to demonstrate that the beta 3-AR in IBAT can be specifically down-regulated in vivo by exposure to a thermogenic agonist.

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Year:  1992        PMID： 1358062      PMCID： PMC1132966          DOI： 10.1042/bj2860743

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

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Authors:  P Muzzin; J P Revelli; C M Fraser; J P Giacobino
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3.  An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity.

Authors:  P Muzzin; J P Revelli; F Kuhne; J D Gocayne; W R McCombie; J C Venter; J P Giacobino; C M Fraser
Journal:  J Biol Chem       Date:  1991-12-15       Impact factor: 5.157

4.  Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.

Authors:  J Gocayne; D A Robinson; M G FitzGerald; F Z Chung; A R Kerlavage; K U Lentes; J Lai; C D Wang; C M Fraser; J C Venter
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

5.  The novel thermogenic beta-adrenergic agonist Ro 16-8714 increases the interscapular brown-fat beta-receptor-adenylate cyclase and the uncoupling-protein mRNA level in obese (fa/fa) Zucker rats.

Authors:  P Muzzin; J P Revelli; D Ricquier; M K Meier; F Assimacopoulos-Jeannet; J P Giacobino
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857

6.  A role for brown adipose tissue in diet-induced thermogenesis.

Authors:  N J Rothwell; M J Stock
Journal:  Nature       Date:  1979-09-06       Impact factor: 49.962

7.  Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline.

Authors:  D O Foster; M L Frydman
Journal:  Can J Physiol Pharmacol       Date:  1978-02       Impact factor: 2.273

8.  Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level.

Authors:  M Bouvier; S Collins; B F O'Dowd; P T Campbell; A de Blasi; B K Kobilka; C MacGregor; G P Irons; M G Caron; R J Lefkowitz
Journal:  J Biol Chem       Date:  1989-10-05       Impact factor: 5.157

9.  Molecular cloning and expression of the rat beta 1-adrenergic receptor gene.

Authors:  C A Machida; J R Bunzow; R P Searles; H Van Tol; B Tester; K A Neve; P Teal; V Nipper; O Civelli
Journal:  J Biol Chem       Date:  1990-08-05       Impact factor: 5.157

10.  Stereospecific stimulation of brown adipocyte respiration by catecholamines via beta 1-adrenoreceptors.

Authors:  L Bukowiecki; N Folléa; A Paradis; A Collet
Journal:  Am J Physiol       Date:  1980-06
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  6 in total

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Review 2.  Agonist-induced desensitisation of β3 -adrenoceptors: Where, when, and how?

Authors:  Katerina Okeke; Stephane Angers; Michel Bouvier; Martin C Michel
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3.  Attenuation of Gs alpha coupling efficiency in brown-adipose-tissue plasma membranes from cold-acclimated hamsters.

Authors:  P Svoboda; L Unelius; B Cannon; J Nedergaard
Journal:  Biochem J       Date:  1993-11-01       Impact factor: 3.857

4.  Down-regulation of beta3-adrenergic receptor expression in rat adipose tissue during the fasted/fed transition: evidence for a role of insulin.

Authors:  K E Hadri; C Charon; J Pairault; S Hauguel-De Mouzon; A Quignard-Boulangé; B Fève
Journal:  Biochem J       Date:  1997-04-15       Impact factor: 3.857

5.  Interaction of nuclear factors with the cAMP response elements of the human β(3)-adrenoceptor gene.

Authors:  E Kutoh; J P Giacobino
Journal:  Endocrine       Date:  1996-12       Impact factor: 3.633

6.  Differential adrenergic regulation of the gene expression of the beta-adrenoceptor subtypes beta1, beta2 and beta3 in brown adipocytes.

Authors:  T Bengtsson; B Cannon; J Nedergaard
Journal:  Biochem J       Date:  2000-05-01       Impact factor: 3.857
  6 in total

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