Literature DB >> 2572217

The novel thermogenic beta-adrenergic agonist Ro 16-8714 increases the interscapular brown-fat beta-receptor-adenylate cyclase and the uncoupling-protein mRNA level in obese (fa/fa) Zucker rats.

P Muzzin1, J P Revelli, D Ricquier, M K Meier, F Assimacopoulos-Jeannet, J P Giacobino.   

Abstract

In obese (fa/fa) rats both the total (-)-isoprenaline- and NaF-stimulated adenylate cyclase activities of interscapular brown-adipose-tissue (IBAT) plasma membranes were decreased as compared with lean rats by 40 and 38% respectively. An acute treatment with Ro 16-8714 increased (-)-isoprenaline- and NaF-stimulated adenylate cyclase activities by 2.5- and 2.0-fold respectively, and beta-adrenoceptor number 2.8-fold in obese rat IBAT, but it had no effect on these parameters in lean rats. It increased mRNA for mitochondrial uncoupling protein in both lean and obese rats to the same extent.

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Year:  1989        PMID： 2572217      PMCID： PMC1138890          DOI： 10.1042/bj2610721

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  35 in total

1.  Detergent solubilization of mammalian cardiac and hepatic beta-adrenergic receptors.

Authors:  W L Strauss; G Ghai; C M Fraser; J C Venter
Journal:  Arch Biochem Biophys       Date:  1979-09       Impact factor: 4.013

2.  Beta-Adrenergic receptors in brown-adipose tissue. Characterization and alterations during acclimation of rats to cold.

Authors:  L Bukowiecki; N Follea; J Vallieres; J Leblanc
Journal:  Eur J Biochem       Date:  1978-12-01

3.  Control of brown fat thermogenesis by the sympathetic nervous system.

Authors:  J Seydoux; L Girardier
Journal:  Experientia Suppl       Date:  1978

4.  Altered effect of insulin and catecholamines in brown adipose tissue of cold-acclimated rats.

Authors:  N Bégin-Heick; I Noland; M Dalpé; H M Heick
Journal:  Can J Physiol Pharmacol       Date:  1979-03       Impact factor: 2.273

5.  A highly sensitive adenylate cyclase assay.

Authors:  Y Salomon; C Londos; M Rodbell
Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

6.  The molecular basis for adrenergic desensitization in hamster brown adipose tissue: uncoupling of adenylate cyclase activation.

Authors:  J Svartengren; P Svoboda; Z Drahota; B Cannon
Journal:  Comp Biochem Physiol C       Date:  1984

7.  A role for brown adipose tissue in diet-induced thermogenesis.

Authors:  N J Rothwell; M J Stock
Journal:  Nature       Date:  1979-09-06       Impact factor: 49.962

8.  Subcellular fractionation of brown adipose tissue.

Authors:  J P Giacobino
Journal:  J Supramol Struct       Date:  1979

9.  The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP.

Authors:  D M Cooper; W Schlegel; M C Lin; M Rodbell
Journal:  J Biol Chem       Date:  1979-09-25       Impact factor: 5.157

10.  Stereospecific stimulation of brown adipocyte respiration by catecholamines via beta 1-adrenoreceptors.

Authors:  L Bukowiecki; N Folléa; A Paradis; A Collet
Journal:  Am J Physiol       Date:  1980-06
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  2 in total

1.  Modulation in vivo of beta-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16-8714.

Authors:  J P Revelli; P Muzzin; J P Giacobino
Journal:  Biochem J       Date:  1992-09-15       Impact factor: 3.857

2.  Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.

Authors:  S R Ross; L Choy; R A Graves; N Fox; V Solevjeva; S Klaus; D Ricquier; B M Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205
  2 in total

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