Literature DB >> 1352980

B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity.

P Onali1, M C Olianas.   

Abstract

In homogenates of female rat anterior pituitary, the azepine derivative B-HT 920 inhibited the forskolin-stimulated adenylate cyclase activity with an EC50 value of 0.35 microM. In male rat anterior pituitary, B-HT 920 curtailed the stimulation of adenylate cyclase activity by vasoactive intestinal peptide with an EC50 of 0.20 microM. In synaptic plasma membranes of rat striatum, B-HT 920 significantly reduced basal adenylate cyclase activity with an EC50 of 0.68 microM. Both in pituitary and striatum, the B-HT 920 inhibition was counteracted by the dopamine (DA) D2 receptor antagonist 1-sulpiride, but not by the alpha 2-adrenergic antagonist yohimbine. These results indicate that B-HT 920 is capable of activating DA D2 receptors negatively coupled to adenylate cyclase activity.

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Year:  1992        PMID： 1352980     DOI： 10.1007/bf01244815

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  29 in total

1.  Effect of BHT 920 on monoaminergic neurons of the rat brain: an electrophysiological in vivo and in vitro study.

Authors:  V Seutin; J Scuvée-Moreau; I Giesbers; L Massotte; A Dresse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-11       Impact factor: 3.000

2.  Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

Authors:  P Sokoloff; B Giros; M P Martres; M L Bouthenet; J C Schwartz
Journal:  Nature       Date:  1990-09-13       Impact factor: 49.962

3.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

4.  Alternative splicing directs the expression of two D2 dopamine receptor isoforms.

Authors:  B Giros; P Sokoloff; M P Martres; J F Riou; L J Emorine; J C Schwartz
Journal:  Nature       Date:  1989 Dec 21-28       Impact factor: 49.962

5.  Selective stimulation of dopamine and noradrenaline autoreceptors by B-HT 920 and B-HT 933, respectively.

Authors:  N E Andén; K Gołembiowska-Nikitin; U Thornström
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-11       Impact factor: 3.000

6.  Dopamine-inhibited adenylate cyclase in female rat adenohypophysis.

Authors:  G Giannattasio; M E De Ferrari; A Spada
Journal:  Life Sci       Date:  1981-04-06       Impact factor: 5.037

7.  Characterization of dopamine receptors mediating inhibition of adenylate cyclase activity in rat striatum.

Authors:  P Onali; M C Olianas; G L Gessa
Journal:  Mol Pharmacol       Date:  1985-08       Impact factor: 4.436

8.  Dopamine inhibition of neurotensin-induced increase in Ca2+ influx into rat pituitary cells.

Authors:  M Memo; E Carboni; M Trabucchi; M O Carruba; P F Spano
Journal:  Brain Res       Date:  1985-11-18       Impact factor: 3.252

9.  Dopaminergic modulation of adenylate cyclase stimulation by vasoactive intestinal peptide in anterior pituitary.

Authors:  P Onali; J P Schwartz; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

10.  Inhibition of K+-stimulated [3H]dopamine and [14C]acetylcholine release by the putative dopamine autoreceptor agonist, B-HT 920.

Authors:  C J Schmidt; A Lobur; W Lovenberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-12       Impact factor: 3.000
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