Literature DB >> 6171819

Dopaminergic modulation of adenylate cyclase stimulation by vasoactive intestinal peptide in anterior pituitary.

P Onali, J P Schwartz, E Costa.   

Abstract

The activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] by vasoactive intestinal peptide (VIP) was used as a model to investigate the molecular mechanisms triggered by the occupancy of dopamine recognition sites in rat anterior pituitary. Dopamine failed to change the basal enzyme activity, but it inhibited the stimulation of adenylate cyclase elicited by VIP. Apomorphine, 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, and 2-bromo-alpha-ergocryptine mimicked the effect of dopamine, whereas (-)-sulpiride and and classical neuroleptics antagonized it. Dopamine failed to modulate the activation of pituitary adenylate cyclase by prostaglandin E1, which does not increase prolactin secretion. From these results we infer that stimulation of D-2 (dopamine) receptors may affect pituitary secretion by inhibiting the activation of anterior pituitary adenylate cyclase by VIP or other secretagogues.

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Year:  1981        PMID： 6171819      PMCID： PMC349074          DOI： 10.1073/pnas.78.10.6531

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

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Authors:  H S Ahn; E Gardner; M H Makman
Journal:  Eur J Pharmacol       Date:  1979-01-15       Impact factor: 4.432

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Authors:  M J Cronin; J M Roberts; R I Weiner
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Review 3.  Multiple receptors for dopamine.

Authors:  J W Kebabian; D B Calne
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4.  Effects of bromocriptine on central dopaminergic receptors.

Authors:  M Trabucchi; P F Spano; G C Tonon; L Frattola
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5.  Effects of lisuride and LSD on cerebral monoamine systems and hallucinosis.

Authors:  L Pieri; H H Keller; W Burkard; M Da Prada
Journal:  Nature       Date:  1978-03-16       Impact factor: 49.962

Review 6.  Studies on the pharmacological properties of dopamine receptors in various areas of the central nervous system.

Authors:  P F Spano; S Govoni; M Trabucchi
Journal:  Adv Biochem Psychopharmacol       Date:  1978

7.  Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release.

Authors:  M G Caron; M Beaulieu; V Raymond; B Gagné; J Drouin; R J Lefkowitz; F Labrie
Journal:  J Biol Chem       Date:  1978-04-10       Impact factor: 5.157

8.  Lergotrile mesylate: an in vivo dopamine agonist which blocks dopamine receptors in vitro.

Authors:  J W Kebabian; D B Calne; P R Kebabian
Journal:  Commun Psychopharmacol       Date:  1977

9.  Prolactin release by vasoactive intestinal polypeptide in rats.

Authors:  Y Kato; Y Iwasaki; J Iwasaki; H Abe; N Yanaihara; H Imura
Journal:  Endocrinology       Date:  1978-08       Impact factor: 4.736

10.  Binding of dopamine to bovine anterior pituitary gland membranes.

Authors:  M A Calabro; R M MacLeod
Journal:  Neuroendocrinology       Date:  1978       Impact factor: 4.914
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  8 in total

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Authors:  P Onali; M C Olianas
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Review 2.  Pharmacological and molecular basis for dopamine D-2 receptor diversity.

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Journal:  Mol Neurobiol       Date:  1990 Fall-Winter       Impact factor: 5.590

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Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

4.  Proceedings of the joint meeting of the Scandinavian and British Pharmacological Societies. Stockholm--Sweden. 5th and 6th July, 1982.

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Journal:  Br J Pharmacol       Date:  1982-09       Impact factor: 8.739

5.  Potassium channels involved in the transduction mechanism of dopamine D2 receptors in rat lactotrophs.

Authors:  L Castelletti; M Memo; C Missale; P F Spano; A Valerio
Journal:  J Physiol       Date:  1989-03       Impact factor: 5.182

Review 6.  The role of vasoactive intestinal polypeptide (VIP) as a hypothalamic neurohormone.

Authors:  S Nicosia; D Oliva; G Giannattasio; A Spada
Journal:  J Endocrinol Invest       Date:  1983-06       Impact factor: 4.256

7.  Nerve growth factor in the anterior pituitary: localization in mammotroph cells and cosecretion with prolactin by a dopamine-regulated mechanism.

Authors:  C Missale; F Boroni; S Sigala; A Buriani; M Fabris; A Leon; R Dal Toso; P Spano
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-30       Impact factor: 11.205

8.  3H-Dopamine binding sites differ in rat striatum and pituitary.

Authors:  P Sokoloff; M P Martres; M Delandre; K Redouane; J C Schwartz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-09       Impact factor: 3.000
  8 in total

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