Literature DB >> 1975644

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

P Sokoloff1, B Giros, M P Martres, M L Bouthenet, J C Schwartz.   

Abstract

A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.

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Year:  1990        PMID： 1975644     DOI： 10.1038/347146a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  486 in total

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