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Literature DB >> 13463253

The preparation, purification, and amino acid sequence of a polypeptide renin substrate.

L T SKEGGS, J R KAHN, K LENTZ, N P SHUMWAY.

Abstract

A purified preparation of a polypeptide renin substrate prepared by tryptic degradation of the protein renin substrate has been analyzed by the fluorodinitrobenzene method and after degradation with renin, carboxypeptidase, and phenylisothiocyanate, has been found to possess the amino acid sequence; asp-arg-val-tyr-ileu-his-pro-phe-his-leu-leu-val-tyr-ser. The first 10 of these amino acids constitutes hypertensin I which is released by cleavage of the leucyl-leucine bond by renin. The remaining 4 amino acids, leu, val, tyr, ser, apparently link hypertensin I to the protein renin substrate.

Entities: Chemical Gene

Keywords: PEPTIDES; PROTEASES

Mesh：

Substances：

Year: 1957 PMID： 13463253 PMCID： PMC2136772 DOI： 10.1084/jem.106.3.439

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

16 in total

The preparation, purification, and amino acid sequence of a polypeptide renin substrate.

1. Corticotropins (ACTH). II. Amino acid composition of alpha-corticotropin.

2. Recent developments in techniques for terminal and sequence studies in peptides and proteins.

3. The purification of hog renin substrate.

4. A method of assaying small amounts of hypertensin.

5. Artificial kidney; construction and operation of an improved continuous dialyzer.

6. The isolation and assay of hypertensin from blood.

7. The purification of hypertensin II.

8. The purification of hypertensin I.

9. Amino acid composition and electrophoretic properties of hypertensin I.

10. The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings.

Review 1. Historical perspective of the renin-angiotensin system.

2. Clinical connotations of the experimental hypertensions.

3. [Angiotensin].

4. [Renin and hypertension, physiological or pathological agents?].

Review 5. The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases.

6. Role of proteolytic enzymes in biological regulation (a review).

7. Isolation and identification of a pepsitensin.

8. Local generation of angiotensin II as a mechanism of regulation of peripheral vascular tone in the rat.

Review 9. Vaccination: a novel strategy for inhibiting the renin-angiotensin-aldosterone system.

10. Morphologic and functional changes of the aortic intima during experimental hypertension.