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Literature DB >> 13201713

The purification of hypertensin I.

L T SKEGGS, W H MARSH, J R KAHN, N P SHUMWAY.

Abstract

The purification of hypertensin I has been described. The final product which is four times as powerful a pressor agent as l-arterenol, is obtained with an over-all recovery of 40 per cent. The product consists of a single component in countercurrent distribution, having a nitrogen content of 15.97 per cent and a specific activity of 7050 Goldblatt units per mg. of N or 1125 units per mg. of solid. Acid hydrolysis and paper chromatography indicate in a preliminary fashion that there are about nine amino acids present in the intact polypeptide.

Entities: Chemical Disease

Keywords: ANGIOTONIN/preparation of

Mesh：

Substances：

Year: 1954 PMID： 13201713 PMCID： PMC2136385 DOI： 10.1084/jem.100.4.363

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

9 in total

1. The extraction and purification of hypertension (angiotonin).

Authors: L C CLARK; C WINKLER; F GOLLAN; R P FOX
Journal: J Biol Chem Date: 1954-02 Impact factor: 5.157

2. A method of assaying small amounts of hypertensin.

Authors: L T SKEGGS; J R KAHN; W H MARSH
Journal: Lab Invest Date: 1953 Mar-Apr Impact factor: 5.662

3. Countercurrent distribution.

Authors: L C CRAIG
Journal: Methods Med Res Date: 1952

4. The isolation of hypertensin from the circulating blood of normal dogs with experimental renal hypertension by dialysis in an artificial kidney.

Authors: L T SKEGGS; J R KAHN; N P SHUMWAY
Journal: Circulation Date: 1951-03 Impact factor: 29.690

5. Artificial kidney; construction and operation of an improved continuous dialyzer.

Authors: L T SKEGGS; J R LEONARDS; C R HEISLER
Journal: Proc Soc Exp Biol Med Date: 1949-12

6. THE RENAL HUMORAL PRESSOR MECHANISM IN MAN. I. PREPARATION AND ASSAY OF HUMAN RENIN, HUMAN HYPERTENSINOGEN, AND HYPERTENSIN.

Authors: L Dexter; F W Haynes; W C Bridges
Journal: J Clin Invest Date: 1945-01 Impact factor: 14.808

7. The isolation and assay of hypertensin from blood.

Authors: L T SKEGGS; J R KAHN; N P SHUMWAY
Journal: J Exp Med Date: 1952-03 Impact factor: 14.307

8. The existence of two forms of hypertensin.

Authors: L T SKEGGS; W H MARSH; J R KAHN; N P SHUMWAY
Journal: J Exp Med Date: 1954-03 Impact factor: 14.307

9. The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings.

Authors: J R KAHN; L T SKEGGS; N P SHUMWAY; P E WISENBAUGH
Journal: J Exp Med Date: 1952-06 Impact factor: 14.307

9 in total

20 in total

10. Fibroblast growth factor stimulates angiotensin converting enzyme expression in vascular smooth muscle cells. Possible mediator of the response to vascular injury.

Authors: R S Fishel; V Thourani; S J Eisenberg; S Y Shai; M A Corson; E G Nabel; K E Bernstein; B C Berk
Journal: J Clin Invest Date: 1995-01 Impact factor: 14.808

The purification of hypertensin I.

1. The extraction and purification of hypertension (angiotonin).

2. A method of assaying small amounts of hypertensin.

3. Countercurrent distribution.

4. The isolation of hypertensin from the circulating blood of normal dogs with experimental renal hypertension by dialysis in an artificial kidney.

5. Artificial kidney; construction and operation of an improved continuous dialyzer.

6. THE RENAL HUMORAL PRESSOR MECHANISM IN MAN. I. PREPARATION AND ASSAY OF HUMAN RENIN, HUMAN HYPERTENSINOGEN, AND HYPERTENSIN.

7. The isolation and assay of hypertensin from blood.

8. The existence of two forms of hypertensin.

9. The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings.

Review 1. Historical perspective of the renin-angiotensin system.

2. THE CHEMISTRY OF RENIN SUBSTRATE.

3. [Renin and hypertension, physiological or pathological agents?].

4. The isolation of a hypertension.

5. Isolation and identification of a pepsitensin.

Review 6. Angiotensin II-mediated signal transduction pathways.

Review 7. Drug discovery in renin-angiotensin system intervention: past and future.

Review 8. [The renin-angiotensin system: methodology and clinical importance].

9. Isolation and amino acid composition of human angiotensin I.

10. Fibroblast growth factor stimulates angiotensin converting enzyme expression in vascular smooth muscle cells. Possible mediator of the response to vascular injury.