Literature DB >> 1320977

The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345, produces antinociceptive and anti-oedema effects in the rat.

P J Birch1, S M Harrison, A G Hayes, H Rogers, M B Tyers.   

Abstract

The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345, has been evaluated for antinociceptive activity in two well-characterized inflammatory pain models in the rat. (+/-)-CP-96,345 abolished carrageenin-induced mechanical hyperalgesia, significantly reduced carrageenin-induced paw oedema and attenuated the second phase of the formalin response. The results suggest that NK1 receptor activation occurs during the induction of inflammatory pain states in the rat.

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Year:  1992        PMID： 1320977      PMCID： PMC1908431          DOI： 10.1111/j.1476-5381.1992.tb09008.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345.

Authors:  I J Beresford; P J Birch; R M Hagan; S J Ireland
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

2.  Species differences in affinities of non-peptide antagonists for substance P receptors.

Authors:  B D Gitter; D C Waters; R F Bruns; N R Mason; J A Nixon; J J Howbert
Journal:  Eur J Pharmacol       Date:  1991-05-17       Impact factor: 4.432

3.  The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats.

Authors:  David Dubuisson; Stephen G Dennis
Journal:  Pain       Date:  1977-12       Impact factor: 6.961

4.  Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: new tools for investigating neurokinin function.

Authors:  R M Hagan; S J Ireland; C C Jordan; I J Beresford; M J Deal; P Ward
Journal:  Neuropeptides       Date:  1991-06       Impact factor: 3.286

5.  A potent nonpeptide antagonist of the substance P (NK1) receptor.

Authors:  R M Snider; J W Constantine; J A Lowe; K P Longo; W S Lebel; H A Woody; S E Drozda; M C Desai; F J Vinick; R W Spencer
Journal:  Science       Date:  1991-01-25       Impact factor: 47.728
  5 in total
  23 in total

Review 1.  Visceral perception: inflammatory and non-inflammatory mediators.

Authors:  L Bueno; J Fioramonti
Journal:  Gut       Date:  2002-07       Impact factor: 23.059

2.  A nociceptive signaling role for neuromedin B.

Authors:  Santosh K Mishra; Sarah Holzman; Mark A Hoon
Journal:  J Neurosci       Date:  2012-06-20       Impact factor: 6.167

3.  Neurophysiology of Cancer Pain: From the Laboratory to the Clinic.

Authors: 
Journal:  Curr Rev Pain       Date:  1999

Review 4.  Novel pharmacological strategies for analgesia.

Authors:  M Perkins; A Dray
Journal:  Ann Rheum Dis       Date:  1996-10       Impact factor: 19.103

5.  Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.

Authors:  U Gether; Y Yokota; X Emonds-Alt; J C Brelière; J A Lowe; R M Snider; S Nakanishi; T W Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

6.  Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580.

Authors:  N M Rupniak; S Boyce; A R Williams; G Cook; J Longmore; G R Seabrook; M Caeser; S D Iversen; R G Hill
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

7.  Block of voltage-dependent sodium currents by the substance P receptor antagonist (+/-)-CP-96,345 in neurones cultured from rat cortex.

Authors:  M Caeser; G R Seabrook; J A Kemp
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

8.  Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors.

Authors:  M Perretti; A Ahluwalia; R J Flower; S Manzini
Journal:  Immunology       Date:  1993-09       Impact factor: 7.397

9.  An isobolographic analysis of the effects of N-methyl-D-aspartate and NK1 tachykinin receptor antagonists on inflammatory hyperalgesia in the rat.

Authors:  K Ren; M J Iadarola; R Dubner
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

10.  Non-specific activity of (+/-)-CP-96,345 in models of pain and inflammation.

Authors:  A Nagahisa; R Asai; Y Kanai; A Murase; M Tsuchiya-Nakagaki; T Nakagaki; T C Shieh; K Taniguchi
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739
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