Literature DB >> 1665729

Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345.

I J Beresford1, P J Birch, R M Hagan, S J Ireland.   

Abstract

The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.

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Year:  1991        PMID： 1665729      PMCID： PMC1908580          DOI： 10.1111/j.1476-5381.1991.tb12423.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  Species differences in affinities of non-peptide antagonists for substance P receptors.

Authors:  B D Gitter; D C Waters; R F Bruns; N R Mason; J A Nixon; J J Howbert
Journal:  Eur J Pharmacol       Date:  1991-05-17       Impact factor: 4.432

Review 2.  Mammalian tachykinin receptors.

Authors:  S Nakanishi
Journal:  Annu Rev Neurosci       Date:  1991       Impact factor: 12.449

3.  Receptors for substance P. I. The pharmacological preparations.

Authors:  D Regoli; P D'Orléans-Juste; E Escher; J Mizrahi
Journal:  Eur J Pharmacol       Date:  1984-01-27       Impact factor: 4.432

4.  A potent nonpeptide antagonist of the substance P (NK1) receptor.

Authors:  R M Snider; J W Constantine; J A Lowe; K P Longo; W S Lebel; H A Woody; S E Drozda; M C Desai; F J Vinick; R W Spencer
Journal:  Science       Date:  1991-01-25       Impact factor: 47.728

5.  Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea.

Authors:  S J Ireland; F Bailey; A Cook; R M Hagan; C C Jordan; M L Stephens-Smith
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

6.  Pharmacological characterization and autoradiographic localization of substance P receptors in guinea pig brain.

Authors:  T V Dam; R Quirion
Journal:  Peptides       Date:  1986 Sep-Oct       Impact factor: 3.750
  6 in total
  41 in total

Review 1.  Role of substance P in inflammatory arthritis.

Authors:  N E Garrett; P I Mapp; S C Cruwys; B L Kidd; D R Blake
Journal:  Ann Rheum Dis       Date:  1992-08       Impact factor: 19.103

2.  Chronic psychosocial stress in tree shrews: effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters.

Authors:  Marieke G C van der Hart; Gabriel de Biurrun; Boldizsár Czéh; Nadia M J Rupniak; Johan A den Boer; Eberhard Fuchs
Journal:  Psychopharmacology (Berl)       Date:  2005-10-14       Impact factor: 4.530

3.  Inhibitory action of (+/-)CP-96,345 on the cardiovascular responses to intrathecal substance P and neuropeptide K in the conscious freely moving rat.

Authors:  T M Pham; R Couture
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

4.  NK1 receptors mediate tachykinin-induced plasma extravasation in the rat knee joint.

Authors:  Y Hirayama; R Yasumitsu; A Kawamura; T Fujii
Journal:  Agents Actions       Date:  1993-11

5.  A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically.

Authors:  S M Moussaoui; F Montier; A Carruette; J C Blanchard; P M Laduron; C Garret
Journal:  Br J Pharmacol       Date:  1993-05       Impact factor: 8.739

6.  Effects of the tachykinin NK1 receptor antagonist, RP 67580, on central cardiovascular and behavioural effects of substance P, neurokinin A and neurokinin B.

Authors:  J Culman; B Wiegand; H Spitznagel; S Klee; T Unger
Journal:  Br J Pharmacol       Date:  1995-03       Impact factor: 8.739

7.  Pharmacological characterization of the contractile responses to angiotensin analogues in guinea-pig isolated longitudinal muscle of small intestine.

Authors:  A B Hawcock; J C Barnes
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

8.  Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.

Authors:  H Inoue; N Nagata; Y Koshihara
Journal:  Inflamm Res       Date:  1996-06       Impact factor: 4.575

9.  Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580.

Authors:  N M Rupniak; S Boyce; A R Williams; G Cook; J Longmore; G R Seabrook; M Caeser; S D Iversen; R G Hill
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

10.  Characterization of sensory neurotransmission and its inhibition via alpha 2B-adrenoceptors and via non-alpha 2-receptors in rabbit iris.

Authors:  H Fuder; M Selbach
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-04       Impact factor: 3.000
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