Literature DB >> 12831879

Recognition of the DNA minor groove by pyrrole-imidazole polyamides.

Peter B Dervan1, Benjamin S Edelson.   

Abstract

Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Minor groove-binding polyamides offer one chemical approach to DNA recognition.

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Year:  2003        PMID： 12831879     DOI： 10.1016/s0959-440x(03)00081-2

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  183 in total

Review 1.  Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.

Authors:  Taco G Uil; Hidde J Haisma; Marianne G Rots
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

2.  Molecular recognition of the nucleosomal "supergroove".

Authors:  Rajeswari S Edayathumangalam; Philipp Weyermann; Joel M Gottesfeld; Peter B Dervan; Karolin Luger
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-20       Impact factor: 11.205

3.  Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

Authors:  Jevgenij A Raskatov; Amanda E Hargrove; Alex Y So; Peter B Dervan
Journal:  J Am Chem Soc       Date:  2012-04-24       Impact factor: 15.419

4.  Structural studies on ligand-DNA systems: A robust approach in drug design.

Authors:  Surat Kumar; Prateek Pandya; Kumud Pandav; Surendra P Gupta; Arun Chopra
Journal:  J Biosci       Date:  2012-07       Impact factor: 1.826

Review 5.  New approaches toward recognition of nucleic acid triple helices.

Authors:  Dev P Arya
Journal:  Acc Chem Res       Date:  2010-11-12       Impact factor: 22.384

6.  Strong and weak hydrogen bonds in drug-DNA complexes: a statistical analysis.

Authors:  Sunil K Panigrahi; Gautam R Desiraju
Journal:  J Biosci       Date:  2007-06       Impact factor: 1.826

7.  Binding studies of a large antiviral polyamide to a natural HPV sequence.

Authors:  Gaofei He; Elena Vasilieva; George Davis Harris; Kevin J Koeller; James K Bashkin; Cynthia M Dupureur
Journal:  Biochimie       Date:  2014-02-26       Impact factor: 4.079

8.  Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture.

Authors:  Timothy P Best; Benjamin S Edelson; Nicholas G Nickols; Peter B Dervan
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-30       Impact factor: 11.205

9.  Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.

Authors:  Chun-Ho Wong; Stacie L Richardson; Yen-Jun Ho; Alex M H Lucas; Tiziano Tuccinardi; Anne M Baranger; Steven C Zimmerman
Journal:  Chembiochem       Date:  2012-10-24       Impact factor: 3.164

10.  Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide.

Authors:  Luke Pett; Konstantinos Kiakos; Vijay Satam; Pravin Patil; Sarah Laughlin-Toth; Matthew Gregory; Michael Bowerman; Kevin Olson; Mia Savagian; Megan Lee; Moses Lee; W David Wilson; Daniel Hochhauser; John A Hartley
Journal:  Biochim Biophys Acta Gene Regul Mech       Date:  2016-10-24       Impact factor: 4.490
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