Literature DB >> 23097190

Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.

Chun-Ho Wong1, Stacie L Richardson, Yen-Jun Ho, Alex M H Lucas, Tiziano Tuccinardi, Anne M Baranger, Steven C Zimmerman.   

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Year:  2012        PMID： 23097190      PMCID： PMC3549434          DOI： 10.1002/cbic.201200602

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  43 in total

1.  Assessment of the sequence dependency for the binding of 2-aminonaphthyridine to the guanine bulge.

Authors:  Kazuhiko Nakatani; Souta Horie; Takashi Murase; Shinya Hagihara; Isao Saito
Journal:  Bioorg Med Chem       Date:  2003-05-15       Impact factor: 3.641

2.  Major groove accessibility of RNA.

Authors:  K M Weeks; D M Crothers
Journal:  Science       Date:  1993-09-17       Impact factor: 47.728

3.  Role for CCG-trinucleotide repeats in the pathogenesis of chronic lymphocytic leukemia.

Authors:  R L Auer; C Jones; R A Mullenbach; D Syndercombe-Court; D W Milligan; C D Fegan; F E Cotter
Journal:  Blood       Date:  2001-01-15       Impact factor: 22.113

Review 4.  Helix geometry, hydration, and G.A mismatch in a B-DNA decamer.

Authors:  G G Privé; U Heinemann; S Chandrasegaran; L S Kan; M L Kopka; R E Dickerson
Journal:  Science       Date:  1987-10-23       Impact factor: 47.728

5.  Relative substituent position on the strength of pi-pi stacking interactions.

Authors:  Benjamin W Gung; Bright U Emenike; Celeste N Alverez; John Rakovan; Kristin Kirschbaum; Nirbhay Jain
Journal:  Tetrahedron Lett       Date:  2010-03-31       Impact factor: 2.415

6.  Small-molecule binding at an abasic site of DNA: strong binding of lumiflavin for improved recognition of thymine-related single nucleotide polymorphisms.

Authors:  N B Sankaran; Yusuke Sato; Fuyuki Sato; Burki Rajendar; Kotaro Morita; Takehiro Seino; Seiichi Nishizawa; Norio Teramae
Journal:  J Phys Chem B       Date:  2009-02-05       Impact factor: 2.991

7.  A Janus-Wedge DNA triplex with A-W1-T and G-W2-C base triplets.

Authors:  Han Chen; Larry W McLaughlin
Journal:  J Am Chem Soc       Date:  2008-09-11       Impact factor: 15.419

8.  Pentamidine reverses the splicing defects associated with myotonic dystrophy.

Authors:  M Bryan Warf; Masayuki Nakamori; Catherine M Matthys; Charles A Thornton; J Andrew Berglund
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-12       Impact factor: 11.205

9.  A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding.

Authors:  Jonathan F Arambula; Sreenivasa Rao Ramisetty; Anne M Baranger; Steven C Zimmerman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-08       Impact factor: 11.205

Review 10.  Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.

Authors:  C E Pearson; R R Sinden
Journal:  Curr Opin Struct Biol       Date:  1998-06       Impact factor: 6.809
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  9 in total

1.  Selective alkylation of T-T mismatched DNA using vinyldiaminotriazine-acridine conjugate.

Authors:  Kazumitsu Onizuka; Akira Usami; Yudai Yamaoki; Tomohito Kobayashi; Madoka E Hazemi; Tomoko Chikuni; Norihiro Sato; Kaname Sasaki; Masato Katahira; Fumi Nagatsugi
Journal:  Nucleic Acids Res       Date:  2018-02-16       Impact factor: 16.971

2.  A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.

Authors:  Long M Luu; Lien Nguyen; Shaohong Peng; JuYeon Lee; Hyang Yeon Lee; Chun-Ho Wong; Paul J Hergenrother; H Y Edwin Chan; Steven C Zimmerman
Journal:  ChemMedChem       Date:  2016-06-01       Impact factor: 3.466

Review 3.  Molecular Therapies for Myotonic Dystrophy Type 1: From Small Drugs to Gene Editing.

Authors:  Mariapaola Izzo; Jonathan Battistini; Claudia Provenzano; Fabio Martelli; Beatrice Cardinali; Germana Falcone
Journal:  Int J Mol Sci       Date:  2022-04-21       Impact factor: 6.208

4.  Selective Small Molecule Recognition of RNA Base Pairs.

Authors:  Hafeez S Haniff; Amanda Graves; Matthew D Disney
Journal:  ACS Comb Sci       Date:  2018-07-31       Impact factor: 3.784

5.  In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models.

Authors:  Àlex L González; Piotr Konieczny; Beatriz Llamusi; Estefanía Delgado-Pinar; José I Borrell; Jordi Teixidó; Enrique García-España; Manuel Pérez-Alonso; Roger Estrada-Tejedor; Rubén Artero
Journal:  PLoS One       Date:  2017-06-05       Impact factor: 3.240

6.  Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1.

Authors:  Yuan Fu; Kali A Miller; Lien Nguyen; Amin Haghighat Jahromi; Long M Luu; Anne M Baranger; Steven C Zimmerman
Journal:  J Med Chem       Date:  2013-11-21       Impact factor: 7.446

7.  A Novel Minor Groove Binder as a Potential Therapeutic Agent for Myotonic Dystrophy Type 1.

Authors:  Ke Li; Sarah B Krueger; Steven C Zimmerman
Journal:  ChemMedChem       Date:  2021-06-10       Impact factor: 3.540

8.  Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.

Authors:  Chun-Ho Wong; Lien Nguyen; Jessie Peh; Long M Luu; Jeannette S Sanchez; Stacie L Richardson; Tiziano Tuccinardi; Ho Tsoi; Wood Yee Chan; H Y Edwin Chan; Anne M Baranger; Paul J Hergenrother; Steven C Zimmerman
Journal:  J Am Chem Soc       Date:  2014-04-22       Impact factor: 15.419

9.  Single-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules.

Authors:  Amin Haghighat Jahromi; Masayoshi Honda; Steven C Zimmerman; Maria Spies
Journal:  Nucleic Acids Res       Date:  2013-05-09       Impact factor: 16.971
  9 in total

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