| Literature DB >> 12824021 |
Uwe J Ries1, Henning W M Priepke, Norbert H Hauel, Sandra Handschuh, Gerhard Mihm, Jean M Stassen, Wolfgang Wienen, Herbert Nar.
Abstract
Quinoxalinone derivatives as prototypes of dual thrombin and factor Xa inhibitors have been discovered. Nanomolar inhibition of both coagulation enzymes resulted in very potent antithrombotic activity in vitro.Entities:
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Year: 2003 PMID： 12824021 DOI： 10.1016/s0960-894x(03)00443-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823