Literature DB >> 1280101

Protein kinase A modulates Ca(2+)- and protein kinase C-dependent amylase release in permeabilized rat pancreatic acini.

A J O'Sullivan1, J D Jamieson.   

Abstract

The role of protein kinase A (PKA) in the release of amylase from permeabilized pancreatic acini was investigated. Addition of cyclic AMP (cAMP) to permeabilized acini resulted in a potentiation of Ca(2+)-dependent amylase release, shifting the Ca2+ dose/response curve leftwards. As with protein kinase C (PKC) activation, this is due to an increase in the time of active discharge. The effect of cAMP was shown to be blocked by two inhibitors of PKA, H89 and the PKI-(5-24)-peptide. At low concentration, cAMP synergizes from phorbol 12-myristate 13-acetate (PMA), while at optimal concentrations cAMP and PMA are additive. PKA and PKC appear to work via similar, but not identical mechanisms.

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Year:  1992        PMID： 1280101      PMCID： PMC1133179          DOI： 10.1042/bj2870403

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

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5.  Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

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6.  Interactions of intracellular mediators of amylase secretion in permeabilized pancreatic acini.

Authors:  M Kitagawa; J A Williams; R C De Lisle
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7.  Phosphorylation of low molecular mass cytosolic proteins by protein kinase C and protein kinase A in the rabbit exocrine pancreas.

Authors:  A G Ederveen; J V van der Leest; S E van Emst-de Vries; J J de Pont
Journal:  Eur J Biochem       Date:  1989-11-06

8.  Activation of protein kinase C is not an absolute requirement for amylase release from permeabilized rat pancreatic acini.

Authors:  A J O'Sullivan; J D Jamieson
Journal:  Biochem J       Date:  1992-07-15       Impact factor: 3.857

9.  Ca2(+)-dependent amylase secretion from pancreatic acinar cells occurs without activation of phospholipase C linked G-proteins.

Authors:  P J Padfield; T G Ding; J D Jamieson
Journal:  Biochem Biophys Res Commun       Date:  1991-01-31       Impact factor: 3.575

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Authors:  E Zieseniss; H Plattner
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  9 in total

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Authors:  Gareth J O Evans; Jeff W Barclay; Gerald R Prescott; Sung-Ro Jo; Robert D Burgoyne; Morris J Birnbaum; Alan Morgan
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4.  Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas.

Authors:  S P Denker; J M McCaffery; G E Palade; P A Insel; M G Farquhar
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6.  Cholecystokinin-stimulated enzyme secretion from dispersed rabbit pancreatic acinar cells: phosphorylation-dependent changes in potency and efficacy.

Authors:  P H Willems; S E Van Emst-de Vries; J J De Pont
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7.  Adenylyl cyclase 6 mediates the action of cyclic AMP-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation.

Authors:  Maria E Sabbatini; Louis D'Alecy; Stephen I Lentz; Tong Tang; John A Williams
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8.  Long-term potentiation of exocytosis and cell membrane repair in fibroblasts.

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9.  Identification of Exo2 as the catalytic subunit of protein kinase A reveals a role for cyclic AMP in Ca(2+)-dependent exocytosis in chromaffin cells.

Authors:  A Morgan; M Wilkinson; R D Burgoyne
Journal:  EMBO J       Date:  1993-10       Impact factor: 11.598
  9 in total

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