Literature DB >> 24521753

Adenylyl cyclases in the digestive system.

Maria Eugenia Sabbatini1, Fred Gorelick2, Shannon Glaser3.   

Abstract

Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Adenylyl cyclase; Exocrine pancreas; Intestine; Liver; Salivary gland; Stomach

Mesh：

Substances：

Year:  2014        PMID： 24521753      PMCID： PMC4441802          DOI： 10.1016/j.cellsig.2014.01.033

Source DB:  PubMed          Journal:  Cell Signal        ISSN： 0898-6568            Impact factor:   4.315


  139 in total

1.  Specific expression of soluble adenylyl cyclase in male germ cells.

Authors:  M L Sinclair; X Y Wang; M Mattia; M Conti; J Buck; D J Wolgemuth; L R Levin
Journal:  Mol Reprod Dev       Date:  2000-05       Impact factor: 2.609

Review 2.  Regulation of cholangiocyte bicarbonate secretion.

Authors:  N Kanno; G LeSage; S Glaser; G Alpini
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2001-09       Impact factor: 4.052

Review 3.  Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase.

Authors:  N Defer; M Best-Belpomme; J Hanoune
Journal:  Am J Physiol Renal Physiol       Date:  2000-09

4.  Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt.

Authors:  Shannon Glaser; Domenico Alvaro; Heather Francis; Yoshiyuki Ueno; Luca Marucci; Antonio Benedetti; Sharon De Morrow; Marco Marzioni; Maria Grazia Mancino; Jo Lynne Phinizy; Ramona Reichenbach; Giammarco Fava; Ryun Summers; Julie Venter; Gianfranco Alpini
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2005-12-08       Impact factor: 4.052

5.  The type 8 adenylyl cyclase is critical for Ca2+ stimulation of cAMP accumulation in mouse parotid acini.

Authors:  E L Watson; K L Jacobson; J C Singh; R Idzerda; S M Ott; D H DiJulio; S T Wong; D R Storm
Journal:  J Biol Chem       Date:  2000-05-12       Impact factor: 5.157

6.  Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase.

Authors:  B S Jaiswal; M Conti
Journal:  J Biol Chem       Date:  2001-06-21       Impact factor: 5.157

7.  Regulation of the Ca2+-inhibitable adenylyl cyclase type VI by capacitative Ca2+ entry requires localization in cholesterol-rich domains.

Authors:  K A Fagan; K E Smith; D M Cooper
Journal:  J Biol Chem       Date:  2000-08-25       Impact factor: 5.157

8.  Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.

Authors:  Y Chen; M J Cann; T N Litvin; V Iourgenko; M L Sinclair; L R Levin; J Buck
Journal:  Science       Date:  2000-07-28       Impact factor: 47.728

9.  Nitric oxide inhibition of cAMP synthesis in parotid acini: regulation of type 5/6 adenylyl cyclase.

Authors:  E L Watson; J C Singh; K L Jacobson; S M Ott
Journal:  Cell Signal       Date:  2001-10       Impact factor: 4.315

Review 10.  Regulatory properties of adenylate cyclases type 5 and 6: A progress report.

Authors:  Michael A Beazely; Val J Watts
Journal:  Eur J Pharmacol       Date:  2006-03-09       Impact factor: 4.432
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  9 in total

1.  Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus.

Authors:  Søren Brandt Poulsen; Tina Bøgelund Kristensen; Heddwen L Brooks; Donald E Kohan; Timo Rieg; Robert A Fenton
Journal:  JCI Insight       Date:  2017-04-06

Review 2.  International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.

Authors:  Carmen W Dessauer; Val J Watts; Rennolds S Ostrom; Marco Conti; Stefan Dove; Roland Seifert
Journal:  Pharmacol Rev       Date:  2017-04       Impact factor: 25.468

Review 3.  Investigation of cAMP microdomains as a path to novel cancer diagnostics.

Authors:  Garrett Desman; Caren Waintraub; Jonathan H Zippin
Journal:  Biochim Biophys Acta       Date:  2014-09-07

4.  T cell exosome-derived miR-142-3p impairs glandular cell function in Sjögren's syndrome.

Authors:  Juan Cortes-Troncoso; Shyh-Ing Jang; Paola Perez; Jorge Hidalgo; Tomoko Ikeuchi; Teresa Greenwell-Wild; Blake M Warner; Niki M Moutsopoulos; Ilias Alevizos
Journal:  JCI Insight       Date:  2020-05-07

Review 5.  Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.

Authors:  Katrina F Ostrom; Justin E LaVigne; Tarsis F Brust; Roland Seifert; Carmen W Dessauer; Val J Watts; Rennolds S Ostrom
Journal:  Physiol Rev       Date:  2021-10-26       Impact factor: 37.312

6.  Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine.

Authors:  Wenjuan Zhang; Qin Tao; Zihu Guo; Yingxue Fu; Xuetong Chen; Piar Ali Shar; Mohamed Shahen; Jinglin Zhu; Jun Xue; Yaofei Bai; Ziyin Wu; Zhenzhong Wang; Wei Xiao; Yonghua Wang
Journal:  Sci Rep       Date:  2016-09-06       Impact factor: 4.379

7.  Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling.

Authors:  Suifang Mao; Alok S Shah; Thomas O Moninger; Lynda S Ostedgaard; Lin Lu; Xiao Xiao Tang; Ian M Thornell; Leah R Reznikov; Sarah E Ernst; Philip H Karp; Ping Tan; Shaf Keshavjee; Mahmoud H Abou Alaiwa; Michael J Welsh
Journal:  Proc Natl Acad Sci U S A       Date:  2018-01-22       Impact factor: 11.205

Review 8.  Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy.

Authors:  Rui Guo; Tian Liu; Marzieh Dehghan Shasaltaneh; Xuan Wang; Saber Imani; QingLian Wen
Journal:  Front Oncol       Date:  2022-06-27       Impact factor: 5.738

9.  Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects.

Authors:  Radia Forteza; M Kaimul Ahsan; Fernando Cartón-García; Diego Arango; Nadia A Ameen; Pedro J Salas
Journal:  Mol Biol Cell       Date:  2019-10-30       Impact factor: 4.138
  9 in total

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