Literature DB >> 1278309

Antischistosomal and some toxicological properties of a nitrodiphenylaminoisothiocyanate (C 9333-Go/CGP 4540).

E Bueding, R Batzinger, G Petterson.   

Abstract

A procedure to enhance the schistosomicidal effectiveness in vivo of an isothiocyanate derivative and some of its antischistosomal properties are reported. Determinations of the effects of this compound on tissue thiol levels and on highly sensitivity bacterial tester strains have indicated that its mutagenic potential is of a low order and that the latter is decreased further after reduction of the host's intestinal bacterial flora.

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Year:  1976        PMID： 1278309     DOI： 10.1007/BF01990188

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  CARCINOGENIC AZO DYES, DYE-BINDING AND LIVER GLUTATHIONE.

Authors:  W J NEISH; H M DAVIES; P M REEVE
Journal:  Biochem Pharmacol       Date:  1964-09       Impact factor: 5.858

2.  Studies of a proteolytic enzyme from Schistosoma mansoni.

Authors:  A R TIMMS; E BUEDING
Journal:  Br J Pharmacol Chemother       Date:  1959-03

3.  Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.

Authors:  J McCann; N E Spingarn; J Kobori; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205

4.  Hycanthone-induced hepatic changes in mice infected with Schistosoma mansoni.

Authors:  W H Haese; D L Smith; E Bueding
Journal:  J Pharmacol Exp Ther       Date:  1973-09       Impact factor: 4.030

5.  Hycanthone resistance: development in Schistosoma mansoni.

Authors:  S H Rogers; E Bueding
Journal:  Science       Date:  1971-06-04       Impact factor: 47.728

6.  Biochemical effects of niridazole on Schistosoma mansoni.

Authors:  E Bueding; J Fisher
Journal:  Mol Pharmacol       Date:  1970-09       Impact factor: 4.436

7.  Clinical evaluation of F30066 in long-course treatment of schistosomiasis japonica.

Authors:  H C Chou; M Huangfu; H L Chou; M H Wei
Journal:  Chin Med J       Date:  1965-09

8.  Carcinogenic effects of niridazole.

Authors:  H K Urman; O Bulay; D B Clayson; P Shubik
Journal:  Cancer Lett       Date:  1975-11       Impact factor: 8.679

9.  4-Isothiocyanato-4'-nitrodiphenylamine (C 9333-Go/CGP 4540), an anthelminthic with an unusual spectrum of activity against intestinal nematodes, filariae and schistosomes.

Authors:  H P Striebel
Journal:  Experientia       Date:  1976-04-15

10.  Detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice.

Authors:  M S Legator; T H Connor; M Stoeckel
Journal:  Science       Date:  1975-06-13       Impact factor: 47.728
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  6 in total

Review 1.  Schistosomiasis--a century searching for chemotherapeutic drugs.

Authors:  Gabriela Ribeiro-dos-Santos; Sergio Verjovski-Almeida; Luciana C C Leite
Journal:  Parasitol Res       Date:  2006-04-25       Impact factor: 2.289

Review 2.  Schistosomiasis drug therapy and treatment considerations.

Authors:  K C Shekhar
Journal:  Drugs       Date:  1991-09       Impact factor: 9.546

3.  Activation of cycasin to a mutagen for Saccharomyces cerevisiae by rat intestinal flora.

Authors:  V W Mayer; C J Goin
Journal:  Appl Environ Microbiol       Date:  1983-02       Impact factor: 4.792

4.  Antischistosomal effects of cyclosporin A.

Authors:  E Bueding; J Hawkins; Y N Cha
Journal:  Agents Actions       Date:  1981-07

5.  4-Isothiocyanato-4'-nitrodiphenylamine (C 9333-Go/CGP 4540), an anthelminthic with an unusual spectrum of activity against intestinal nematodes, filariae and schistosomes.

Authors:  H P Striebel
Journal:  Experientia       Date:  1976-04-15

6.  Chemotherapeutic effects of 4-isothiocyanato-4'-nitrodiphenylamine (C9333-Go/CGP 4540) on infections with Nematospiroides dubius, Hymenolepis diminuta, Hymenolepis nana and Spirometra mansonoides.

Authors:  K R Middleton; F W Schaefer; H J Saz
Journal:  Experientia       Date:  1979-02-15
  6 in total

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