Literature DB >> 766186

Detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice.

M S Legator, T H Connor, M Stoeckel.   

Abstract

After humans were treated at therapeutic doses with the trichomonacide metronidazole (Flagyl) and the antischistosomal agent niridazole mutagenic activity was demonstrable in their urines when tested with the histidine auxotroph of Salmonella typhimurium. Both compounds were active in the host-mediated assay in mice, and evidence of activity was found in the blood and urine of mice treated with niridazole but not with metronidazole.

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Year:  1975        PMID： 766186     DOI： 10.1126/science.766186

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  22 in total

Review 1.  Antibiotics and breast-feeding: a critical review of the literature.

Authors:  Allison M Chung; Michael D Reed; Jeffrey L Blumer
Journal:  Paediatr Drugs       Date:  2002       Impact factor: 3.022

2.  Anti-anaerobic antimicrobial agents: cefoxitin, cefotetan, clindamycin, and metronidazole.

Authors:  J A Bosso; R A Prince
Journal:  Tex Heart Inst J       Date:  1990

3.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Authors:  J McCann; E Choi; E Yamasaki; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

4.  The in vitro anti-giardial activity of extracts from plants that are used for self-medication by AIDS patients in southern Thailand.

Authors:  N Sawangjaroen; S Subhadhirasakul; S Phongpaichit; C Siripanth; K Jamjaroen; K Sawangjaroen
Journal:  Parasitol Res       Date:  2004-11-18       Impact factor: 2.289

5.  Antischistosomal and some toxicological properties of a nitrodiphenylaminoisothiocyanate (C 9333-Go/CGP 4540).

Authors:  E Bueding; R Batzinger; G Petterson
Journal:  Experientia       Date:  1976-05-15

6.  Antiamoebic and toxicity studies of a carbamic acid derivative and its therapeutic effect in a hamster model of hepatic amoebiasis.

Authors:  Cynthia Ordaz-Pichardo; Mineko Shibayama; Saúl Villa-Treviño; Myriam Arriaga-Alba; Enrique Angeles; Mireya de la Garza
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

Review 7.  Trichomonas vaginalis and trichomoniasis in the Republic of Korea.

Authors:  Jae-Sook Ryu; Duk-Young Min
Journal:  Korean J Parasitol       Date:  2006-06       Impact factor: 1.341

8.  Antibacterial effects of niridazole: its effect on microaerophilic campylobacter.

Authors:  H Hof; V Sticht-Groh
Journal:  Infection       Date:  1984 Jan-Feb       Impact factor: 3.553

9.  Absence of strand breaks in deoxyribonucleic acid treated with metronidazole.

Authors:  N F LaRusso; M Tomasz; D Kaplan; M Müller
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191

10.  Antitrichomonad action, mutagenicity, and reduction of metronidazole and other nitroimidazoles.

Authors:  D G Lindmark; M Müller
Journal:  Antimicrob Agents Chemother       Date:  1976-09       Impact factor: 5.191
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