| Literature DB >> 7282489 |
E Bueding, J Hawkins, Y N Cha.
Abstract
Administration of cyclosporin A, a new selective immunosuppressive agent, to mice infected with Schistosoma mansoni resulted in a significant reduction in the number of mature and immature male and, to a greater extent, female worms. With lower, subeffective, doses a reduction in hemoglobinase activity and protein content of female schistosomes is produced. Evidence available so far suggests that the antischistosomal effects of cyclosporin A are mediated through a stimulation of host mechanisms directed against the parasite.Entities:
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Year: 1981 PMID： 7282489 DOI： 10.1007/BF01982474
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299