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Literature DB >> 1275488

Teratogenicity of patulin and patulin adducts formed with cysteine.

Abstract

The mean lethal dose of patulin for the chicken embryo injected in the air cell before incubation was determined to be 68.7 mug and that for the 4-day-old embryo was 2.35 mug. Both patulin (1 to 2 mug/egg) and the reaction mixture between patulin and cysteine (15 to 150 mug of patulin equivalents) were teratogenic to the chicken embryo. At least two ninhydrin-negative and four ninhydrin-positive products were formed during the latter reaction. Our explanation of the reaction mechanism remains to be elaborated.

Entities: Chemical Species

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Year: 1976 PMID： 1275488 PMCID： PMC291173 DOI： 10.1128/aem.31.5.664-667.1976

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

12 in total

1. Isolation of amino acids by chromatography on ion exchange columns; use of volatile buffers.

Authors: C H W HIRS; S MOORE; W H STEIN
Journal: J Biol Chem Date: 1952-04 Impact factor: 5.157

2. Inhibition of alcohol and lactic dehydrogenases by patulin and penicillic acid in vitro.

Authors: S H Ashoor; F S Chu
Journal: Food Cosmet Toxicol Date: 1973-08

3. Effects of rubratoxin B on prenatal development in mice.

Authors: R D Hood; J E Innes; A W Hayes
Journal: Bull Environ Contam Toxicol Date: 1973-10 Impact factor: 2.151

4. Inhibition of muscle aldolase by penicillic acid and patulin in vitro.

Authors: S H Ashoor; F S Chu
Journal: Food Cosmet Toxicol Date: 1973-12

5. Potential production and detoxification of penicillic acid in mold-fermented sausage (salami).

Authors: A Ciegler; H J Mintzlaff; D Weisleder; L Leistner
Journal: Appl Microbiol Date: 1972-07

6. Occurrence of patulin in apple juice.

Authors: P M Scott; W F Miles; P Toft; J G Dubé
Journal: J Agric Food Chem Date: 1972 Mar-Apr Impact factor: 5.279

7. Carcinogenicity of lactones. 3. The reactions of unsaturated gamma-lactones with L-cysteine.

Authors: J B Jones; J M Young
Journal: J Med Chem Date: 1968-11 Impact factor: 7.446

8. Teratogenic effects of ochratoxin A in mice.

Authors: A W Hayes; R D Hood; H L Lee
Journal: Teratology Date: 1974-02

9. Studies on latent derivatives of aminoethanethiols as potentially selective cytoprotectants. I. A spectrophotometric assay for aminoethanethiols in biologic media.

Authors: K A Herrington; K Pointer; A Meister; O M Friedman
Journal: Cancer Res Date: 1967-01 Impact factor: 12.701

10. Teratogenic response by hamsters, rats and mice to aflatoxin B1.

Authors: J A DiPaolo; J Elis; H Erwin
Journal: Nature Date: 1967-08-05 Impact factor: 49.962

21 in total

1. Effect of the incubation conditions on the production of patulin by Penicillium griseofulvum isolated from wheat.

Authors: M Jiménez; R Mateo; J J Mateo; T Huerta; E Hernández
Journal: Mycopathologia Date: 1991-09 Impact factor: 2.574

2. Effects of ascorbic acid on patulin in aqueous solution and in cloudy apple juice.

Authors: Christelle El Hajj Assaf; Nikki De Clercq; Christof Van Poucke; Geertrui Vlaemynck; Els Van Coillie; Els Van Pamel
Journal: Mycotoxin Res Date: 2019-05-23 Impact factor: 3.833

3. Disappearance of patulin during alcoholic fermentation of apple juice.

Authors: E E Stinson; S F Osman; C N Huhtanen; D D Bills
Journal: Appl Environ Microbiol Date: 1978-10 Impact factor: 4.792

Review 4. Biological activities of mycotoxins.

Authors: A W Hayes
Journal: Mycopathologia Date: 1978-12-18 Impact factor: 2.574