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Literature DB >> 18338058

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition.

Zoë A E Waller¹, Pravin S Shirude, Raphaël Rodriguez, Shankar Balasubramanian.

Abstract

The triarylpyridines are potent G-quadruplex ligands that are highly discriminating against duplex DNA and show promising selectivity between intramolecular quadruplexes.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Ligands
Pyridines
DNA

Year: 2008 PMID： 18338058 PMCID： PMC2527513 DOI： 10.1039/b718854d

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

29 in total

1. Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat.

Authors: J L Mergny; J C Maurizot
Journal: Chembiochem Date: 2001-02-02 Impact factor: 3.164

2. Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.

Authors: Mu-Yong Kim; Hariprasad Vankayalapati; Kazuo Shin-Ya; Konstanty Wierzba; Laurence H Hurley
Journal: J Am Chem Soc Date: 2002-03-13 Impact factor: 15.419

3. Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer.

Authors: Liming Ying; Jeremy J Green; Haitao Li; David Klenerman; Shankar Balasubramanian
Journal: Proc Natl Acad Sci U S A Date: 2003-11-25 Impact factor: 11.205

4. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.

Authors: Adam Siddiqui-Jain; Cory L Grand; David J Bearss; Laurence H Hurley
Journal: Proc Natl Acad Sci U S A Date: 2002-08-23 Impact factor: 11.205

5. G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection.

Authors: James A Schouten; Sylvain Ladame; Stephen J Mason; Matthew A Cooper; Shankar Balasubramanian
Journal: J Am Chem Soc Date: 2003-05-14 Impact factor: 15.419

6. Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle.

Authors: Marie-Paule Teulade-Fichou; Carolina Carrasco; Lionel Guittat; Christian Bailly; Patrizia Alberti; Jean-Louis Mergny; Arnaud David; Jean-Marie Lehn; W David Wilson
Journal: J Am Chem Soc Date: 2003-04-23 Impact factor: 15.419

7. Interaction of telomestatin with the telomeric single-strand overhang.

Authors: Dennis Gomez; Rajaa Paterski; Thibault Lemarteleur; Kazuo Shin-Ya; Jean-Louis Mergny; Jean-François Riou
Journal: J Biol Chem Date: 2004-07-23 Impact factor: 5.157

8. Inhibition of human telomerase by a G-quadruplex-interactive compound.

Authors: D Sun; B Thompson; B E Cathers; M Salazar; S M Kerwin; J O Trent; T C Jenkins; S Neidle; L H Hurley
Journal: J Med Chem Date: 1997-07-04 Impact factor: 7.446

9. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

Authors: Angelika M Burger; Fangping Dai; Christoph M Schultes; Anthony P Reszka; Michael J Moore; John A Double; Stephen Neidle
Journal: Cancer Res Date: 2005-02-15 Impact factor: 12.701

10. Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism.

Authors: Qianfan Yang; Junfeng Xiang; Shu Yang; Qian Li; Qiuju Zhou; Aijiao Guan; Xiufeng Zhang; Hong Zhang; Yalin Tang; Guangzhi Xu
Journal: Nucleic Acids Res Date: 2009-11-19 Impact factor: 16.971

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition.

1. Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat.

2. Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.

3. Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer.

4. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.

5. G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection.

6. Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle.

7. Interaction of telomestatin with the telomeric single-strand overhang.

8. Inhibition of human telomerase by a G-quadruplex-interactive compound.

9. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

10. Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands.

1. In silico identification of novel ligands for G-quadruplex in the c-MYC promoter.

2. Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.

3. Aminoglycoside binding to Oxytricha nova telomeric DNA.

4. Selective recognition of a DNA G-quadruplex by an engineered antibody.

5. Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates.

Review 6. Modulation of DNA structure formation using small molecules.

7. A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression.

Review 8. G-quadruplex virtual drug screening: A review.

9. G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells.

10. Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism.