| Literature DB >> 12730693 |
Owen J Sansom1, Jennifer Berger, Stefan M Bishop, Brian Hendrich, Adrian Bird, Alan R Clarke.
Abstract
Gene silencing through de novo methylation of CpG island promoters contributes to cancer. We find that Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the mouse intestine. As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance.Entities:
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Year: 2003 PMID： 12730693 DOI： 10.1038/ng1155
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330