Literature DB >> 27190044

All Things in Moderation: Prevention of Intestinal Adenomas by DNA Hypomethylation.

Kwang-Ho Lee1, Peter W Laird2.   

Abstract

DNA hypomethylation can prevent intestinal tumorigenesis, presumably by reducing epigenetic silencing of tumor-suppressor genes. A study in this issue by Sheaffer and colleagues challenges this notion by showing that severe DNA hypomethylation by tissue-specific Dnmt1 knockout can actually promote intestinal adenoma formation. Cancer Prev Res; 9(7); 509-11. ©2016 AACRSee related article by Sheaffer, et al., p. 534. ©2016 American Association for Cancer Research.

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Year:  2016        PMID： 27190044      PMCID： PMC5784773          DOI： 10.1158/1940-6207.CAPR-16-0097

Source DB:  PubMed          Journal:  Cancer Prev Res (Phila)        ISSN： 1940-6215


  18 in total

1.  Chromosomal instability and tumors promoted by DNA hypomethylation.

Authors:  Amir Eden; François Gaudet; Alpana Waghmare; Rudolf Jaenisch
Journal:  Science       Date:  2003-04-18       Impact factor: 47.728

2.  Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice.

Authors:  Cindy A Eads; Andrea E Nickel; Peter W Laird
Journal:  Cancer Res       Date:  2002-03-01       Impact factor: 12.701

3.  Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.

Authors:  Yasuhiro Yamada; Laurie Jackson-Grusby; Heinz Linhart; Alex Meissner; Amir Eden; Haijiang Lin; Rudolf Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-08       Impact factor: 11.205

4.  Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains.

Authors:  Benjamin P Berman; Daniel J Weisenberger; Joseph F Aman; Toshinori Hinoue; Zachary Ramjan; Yaping Liu; Houtan Noushmehr; Christopher P E Lange; Cornelis M van Dijk; Rob A E M Tollenaar; David Van Den Berg; Peter W Laird
Journal:  Nat Genet       Date:  2011-11-27       Impact factor: 38.330

5.  Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.

Authors:  Gerda Egger; Shinwu Jeong; Sonia G Escobar; Connie C Cortez; Tony W H Li; Yoshimasa Saito; Christine B Yoo; Peter A Jones; Gangning Liang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-08       Impact factor: 11.205

Review 6.  The fundamental role of epigenetic events in cancer.

Authors:  Peter A Jones; Stephen B Baylin
Journal:  Nat Rev Genet       Date:  2002-06       Impact factor: 53.242

7.  Deficiency of Mbd2 suppresses intestinal tumorigenesis.

Authors:  Owen J Sansom; Jennifer Berger; Stefan M Bishop; Brian Hendrich; Adrian Bird; Alan R Clarke
Journal:  Nat Genet       Date:  2003-06       Impact factor: 38.330

8.  Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.

Authors:  L K Su; K W Kinzler; B Vogelstein; A C Preisinger; A R Moser; C Luongo; K A Gould; W F Dove
Journal:  Science       Date:  1992-05-01       Impact factor: 47.728

9.  Increased methylation variation in epigenetic domains across cancer types.

Authors:  Kasper Daniel Hansen; Winston Timp; Héctor Corrada Bravo; Sarven Sabunciyan; Benjamin Langmead; Oliver G McDonald; Bo Wen; Hao Wu; Yun Liu; Dinh Diep; Eirikur Briem; Kun Zhang; Rafael A Irizarry; Andrew P Feinberg
Journal:  Nat Genet       Date:  2011-06-26       Impact factor: 38.330

10.  The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium.

Authors:  Ellen N Elliott; Karyn L Sheaffer; Klaus H Kaestner
Journal:  Elife       Date:  2016-01-25       Impact factor: 8.140
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