Literature DB >> 1270456

Tissue response to implanted polymers: the significance of sample shape.

B F Matlaga, L P Yasenchak, T N Salthouse.   

Abstract

Studies were designed to demonstrate the need for standardization of shape of samples used as implants to evaluate histotoxicity of polymer materials. Six medical-grade polymers (polypropylene, polyethylene, polyurethane, silicone rubber, poly(vinyl chloride), and Teflon) were extruded as rods with circular-, triangular-, and pentagonal-shaped cross sections, and were implanted in rat gluteal muscles for 14 days. Evaluation of the tissue response was assessed by quantitating cellular lysosomal acid phosphatase enzyme activity by using microspectrophotometry. All triangular-shaped implants showed the highest enzyme activity and cellular response; pentagon shapes showed less, and circular rods showed the lowest activity. The results demonstrate the need for standard sample shape for valid comparative studies of tissue response to implanted polymers.

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Year:  1976        PMID： 1270456     DOI： 10.1002/jbm.820100308

Source DB:  PubMed          Journal:  J Biomed Mater Res        ISSN： 0021-9304


  32 in total

1.  Short-term and long-term effects of orthopedic biodegradable implants.

Authors:  Ami R Amini; James S Wallace; Syam P Nukavarapu
Journal:  J Long Term Eff Med Implants       Date:  2011

Review 2.  Biomechanics of the sensor-tissue interface-effects of motion, pressure, and design on sensor performance and the foreign body response-part I: theoretical framework.

Authors:  Kristen L Helton; Buddy D Ratner; Natalie A Wisniewski
Journal:  J Diabetes Sci Technol       Date:  2011-05-01

Review 3.  Biomechanics of the sensor-tissue interface-effects of motion, pressure, and design on sensor performance and foreign body response-part II: examples and application.

Authors:  Kristen L Helton; Buddy D Ratner; Natalie A Wisniewski
Journal:  J Diabetes Sci Technol       Date:  2011-05-01

4.  Functionalizable hydrogel microparticles of tunable size and stiffness for soft-tissue filler applications.

Authors:  Ka Man Carmen Chan; Randolph H Li; Joseph W Chapman; Eric M Trac; James B Kobler; Steven M Zeitels; Robert Langer; Sandeep S Karajanagi
Journal:  Acta Biomater       Date:  2014-02-21       Impact factor: 8.947

Review 5.  Nanotechnology in cell replacement therapies for type 1 diabetes.

Authors:  Alexander U Ernst; Daniel T Bowers; Long-Hai Wang; Kaavian Shariati; Mitchell D Plesser; Natalie K Brown; Tigran Mehrabyan; Minglin Ma
Journal:  Adv Drug Deliv Rev       Date:  2019-02-02       Impact factor: 15.470

6.  Scaffold-Assisted Ectopic Transplantation of Internal Organs and Patient-Derived Tumors.

Authors:  Ryan Carpenter; Hye Jeong Oh; In-Hye Ham; Daeyoung Kim; Hoon Hur; Jungwoo Lee
Journal:  ACS Biomater Sci Eng       Date:  2019-11-13

7.  Electrical properties of implant encapsulation tissue.

Authors:  W M Grill; J T Mortimer
Journal:  Ann Biomed Eng       Date:  1994 Jan-Feb       Impact factor: 3.934

8.  Short-term in vitro and in vivo biocompatibility of a biodegradable polyurethane foam based on 1,4-butanediisocyanate.

Authors:  B van Minnen; M B M van Leeuwen; B Stegenga; J Zuidema; C E Hissink; T G van Kooten; R R M Bos
Journal:  J Mater Sci Mater Med       Date:  2005-03       Impact factor: 3.896

Review 9.  Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction.

Authors:  Wei Chen; Bryant C Yung; Zhiyong Qian; Xiaoyuan Chen
Journal:  Adv Drug Deliv Rev       Date:  2018-01-31       Impact factor: 15.470

10.  Blood flow in the foreign-body capsules surrounding surgically implanted subcutaneous devices.

Authors:  Carlo R Bartoli; John J Godleski
Journal:  J Surg Res       Date:  2010-01       Impact factor: 2.192
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