Literature DB >> 12654691

Trypanocidal and leishmanicidal properties of substitution-containing chalcones.

Fabiane Lunardi1, Michel Guzela, Andrea T Rodrigues, Rogério Corrêa, Iriane Eger-Mangrich, Mário Steindel, Edmundo C Grisard, Jamil Assreuy, João B Calixto, Adair R S Santos.   

Abstract

Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of Leishmania braziliensis and Trypanosoma cruzi with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12654691      PMCID： PMC152493          DOI： 10.1128/AAC.47.4.1449-1451.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

Review 1.  Bioactivities of chalcones.

Authors:  J R Dimmock; D W Elias; M A Beazely; N M Kandepu
Journal:  Curr Med Chem       Date:  1999-12       Impact factor: 4.530

2.  Characterization of Leishmania sp. strains isolated from autochthonous cases of human cutaneous leishmaniasis in Santa Catarina State, southern Brazil.

Authors:  E C Grisard; M Steindel; J J Shaw; E A Ishikawa; C J Carvalho-Pinto; I Eger-Mangrich; H K Toma; J H Lima; A J Romanha; D A Campbell
Journal:  Acta Trop       Date:  2000-01-05       Impact factor: 3.112

3.  Antinociceptive properties of chalcones. Structure-activity relationships.

Authors:  R Corrêa; M A Pereira; D Buffon; L dos Santos; V Cechinell Filho; A R Santos; R J Nunes
Journal:  Arch Pharm (Weinheim)       Date:  2001-10       Impact factor: 3.751

4.  Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones.

Authors:  M Chen; L Zhai; S B Christensen; T G Theander; A Kharazmi
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

Review 5.  The trypanosomatidae: amazing organisms.

Authors:  F R Opperdoes
Journal:  J Bioenerg Biomembr       Date:  1994-04       Impact factor: 2.945

6.  Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania.

Authors:  M Chen; S B Christensen; J Blom; E Lemmich; L Nadelmann; K Fich; T G Theander; A Kharazmi
Journal:  Antimicrob Agents Chemother       Date:  1993-12       Impact factor: 5.191

7.  Fumarate reductase and other mitochondrial activities in Trypanosoma cruzi.

Authors:  A Boveris; C M Hertig; J F Turrens
Journal:  Mol Biochem Parasitol       Date:  1986-05       Impact factor: 1.759

8.  Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani.

Authors:  M Chen; S B Christensen; T G Theander; A Kharazmi
Journal:  Antimicrob Agents Chemother       Date:  1994-06       Impact factor: 5.191

9.  Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection.

Authors:  M Chen; T G Theander; S B Christensen; L Hviid; L Zhai; A Kharazmi
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191

10.  Cell mediated cytotoxicity against U 937 cells by human monocytes and macrophages in a modified colorimetric MTT assay. A methodological study.

Authors:  A A van de Loosdrecht; E Nennie; G J Ossenkoppele; R H Beelen; M M Langenhuijsen
Journal:  J Immunol Methods       Date:  1991-07-26       Impact factor: 2.303
View more
  10 in total

1.  Activity of synthetic chalcones in hamsters experimentally infected with Leishmania (Viannia) braziliensis.

Authors:  Tatiane F P de Mello; Bruna M Cardoso; Sara N Lopes; Heriberto R Bitencourt; Evandra M Voltarelli; Luzmarina Hernandes; Sandra M A Aristides; Maria V C Lonardoni; Thais G V Silveira
Journal:  Parasitol Res       Date:  2015-06-23       Impact factor: 2.289

2.  One-pot diastreoselective synthesis of highly functionalized cyclohexenones: 2-oxo-N,4,6-triarylcyclohex-3-enecarboxamides.

Authors:  Mir Rasul Mousavi; Malek Taher Maghsoodlou; Sayyed Mostafa Habibi-Khorassani
Journal:  Mol Divers       Date:  2014-08-06       Impact factor: 2.943

3.  (E)-3-[4-(Dimethyl-amino)phen-yl]-1-(4-methyl-phen-yl)prop-2-en-1-one.

Authors:  Lei Wang; Li-Ying Ma; Yu-Ling Huang; Bai-Yu Zheng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-16

4.  3-[4-(Dimethyl-amino)phen-yl]-1-(2-pyrrol-yl)prop-2-en-1-one.

Authors:  Si-Ping Tang; Dai-Zhi Kuang; Yong-Lan Feng; Wei Li; Zhi-Min Chen
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-05-21

5.  3-Phenyl-1-(pyrrol-2-yl)prop-2-en-1-one.

Authors:  Zhen-Qi Gong; Gou-Sheng Liu; Hong-Ying Xia
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

6.  Leishmania amazonensis growth inhibitors: biological and theoretical features of sulfonamide 4-methoxychalcone derivatives.

Authors:  Alessandra M T Souza; Helena C Castro; Monique A Brito; Carla R Andrighetti-Fröhner; Uiaran Magalhães; Kely N Oliveira; Daniela Gaspar-Silva; Letícia K Pacheco; Antônio C Joussef; Mário Steindel; Cláudia M O Simões; Dilvani O Santos; Magaly G Albuquerque; Carlos R Rodrigues; Ricardo J Nunes
Journal:  Curr Microbiol       Date:  2009-07-23       Impact factor: 2.188

7.  The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria.

Authors:  Gaber El-Saber Batiha; Amany Magdy Beshbishy; Dickson Stuart Tayebwa; Oluyomi Stephen Adeyemi; Hazem Shaheen; Naoaki Yokoyama; Ikuo Igarashi
Journal:  PLoS Negl Trop Dis       Date:  2019-05-24

8.  Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L.

Authors:  Neera Raghav; Ravinder Kaur
Journal:  Int J Biol Macromol       Date:  2015-07-18       Impact factor: 6.953

9.  Synthesis and antimicrobial evaluation of some novel bis-α,β-unsaturated ketones, nicotinonitrile, 1,2-dihydropyridine-3-carbonitrile, fused thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives.

Authors:  Farag M A Altalbawy
Journal:  Int J Mol Sci       Date:  2013-01-30       Impact factor: 5.923

10.  Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some N-Substituted-4-Phenothiazine-Chalcones.

Authors:  Thai-Son Tran; Minh-Tri Le; Thi-Cam-Vi Nguyen; The-Huan Tran; Thanh-Dao Tran; Khac-Minh Thai
Journal:  Molecules       Date:  2020-08-27       Impact factor: 4.411
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.