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Literature DB >> 10519918

Bioactivities of chalcones.

J R Dimmock¹, D W Elias, M A Beazely, N M Kandepu.

Abstract

This review outlines the different bioactivities of a variety of chalcones. The cytotoxic, anticancer, chemopreventative and mutagenic properties of a number of chalcones are described followed by an account of various of these unsaturated ketones as antimicrobial agents. The antiviral, antiprotozoal and insecticidal activities of a variety of chalcones are reviewed as well as the enzyme-inhibitory properties and miscellaneous activities of some of these molecules.

Entities: Chemical

Mesh：

Substances：

Year: 1999 PMID： 10519918

Source DB: PubMed Journal: Curr Med Chem ISSN： 0929-8673 Impact factor: 4.530

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Cited

113 in total

1. Trypanocidal and leishmanicidal properties of substitution-containing chalcones.

Authors: Fabiane Lunardi; Michel Guzela; Andrea T Rodrigues; Rogério Corrêa; Iriane Eger-Mangrich; Mário Steindel; Edmundo C Grisard; Jamil Assreuy; João B Calixto; Adair R S Santos
Journal: Antimicrob Agents Chemother Date: 2003-04 Impact factor: 5.191

2. Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.

Authors: Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; Carlota Lopez Cara; Maria Dora Carrion; Jan Balzarini; Ernest Hamel; Giuseppe Basso; Roberta Bortolozzi; Giampietro Viola
Journal: Bioorg Med Chem Lett Date: 2010-03-25 Impact factor: 2.823

Review 3. The role of chalcones in suppression of NF-κB-mediated inflammation and cancer.

Authors: Vivek R Yadav; Sahdeo Prasad; Bokyung Sung; Bharat B Aggarwal
Journal: Int Immunopharmacol Date: 2010-12-22 Impact factor: 4.932

4. Methoxychalcone inhibitors of androgen receptor translocation and function.

Authors: Yeong Sang Kim; Vineet Kumar; Sunmin Lee; Aki Iwai; Len Neckers; Sanjay V Malhotra; Jane B Trepel
Journal: Bioorg Med Chem Lett Date: 2012-01-21 Impact factor: 2.823

5. 2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways.

Authors: Remy Kachadourian; Subbiah Pugazhenthi; Kalpana Velmurugan; Donald S Backos; Christopher C Franklin; Joe M McCord; Brian J Day
Journal: Free Radic Biol Med Date: 2011-06-13 Impact factor: 7.376

6. Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.

Authors: Sultan Nacak Baytas; Nazan Inceler; Akin Yilmaz; Abdurrahman Olgac; Sevda Menevse; Erden Banoglu; Ernest Hamel; Roberta Bortolozzi; Giampietro Viola
Journal: Bioorg Med Chem Date: 2014-04-20 Impact factor: 3.641

Bioactivities of chalcones.

1. Trypanocidal and leishmanicidal properties of substitution-containing chalcones.

2. Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.

Review 3. The role of chalcones in suppression of NF-κB-mediated inflammation and cancer.

4. Methoxychalcone inhibitors of androgen receptor translocation and function.

5. 2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways.

6. Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.

Review 7. 1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.

Review 8. Molecular targeted approaches to cancer therapy and prevention using chalcones.

9. Chalcones enhance TRAIL-induced apoptosis in prostate cancer cells.

Review 10. Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.