| Literature DB >> 12614152 |
Heidi R Bokesch1, Barry R O'Keefe, Tawnya C McKee, Lewis K Pannell, Gregory M L Patterson, Roberta S Gardella, Raymond C Sowder, Jim Turpin, Karen Watson, Robert W Buckheit, Michael R Boyd.
Abstract
A new anti-HIV protein, scytovirin, was isolated from aqueous extracts of the cultured cyanobacterium Scytonema varium. The protein displayed potent anticytopathic activity against laboratory strains and primary isolates of HIV-1 with EC50 values ranging from 0.3 to 22 nM. Scytovirin binds to viral coat proteins gp120, gp160, and gp41 but not to cellular receptor CD4 or other tested proteins. This unique protein consists of a single 95-amino acid chain with significant internal sequence duplication and 10 cysteines forming five intrachain disulfide bonds.Entities:
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Year: 2003 PMID： 12614152 DOI： 10.1021/bi0205698
Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162