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Literature DB >> 24284326

Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses.

Stig M R Jensen¹, Francis W Ruscetti, Alan Rein, Daniel C Bertolette, Carrie J Saucedo, Barry R O'Keefe, Kathryn S Jones.

Abstract

The antiviral lectins griffithsin (GRFT), cyanovirin-N (CV-N), and scytovirin (SVN), which inhibit several enveloped viruses, including lentiviruses, were examined for their ability to inhibit entry mediated by Env proteins of delta- and gammaretroviruses. The glycoproteins from human T-cell leukemia virus type 1 (HTLV-1) were resistant to the antiviral effects of all three lectins. For gammaretroviruses, CV-N inhibited entry mediated by some but not all of the envelopes examined, whereas GRFT and SVN displayed only little or no effect.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2013 PMID： 24284326 PMCID： PMC3911537 DOI： 10.1128/JVI.02553-13

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

48 in total

1. Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp.

Authors: Toshiyuki Mori; Barry R O'Keefe; Raymond C Sowder; Scott Bringans; Roberta Gardella; Shannon Berg; Pamela Cochran; Jim A Turpin; Robert W Buckheit; James B McMahon; Michael R Boyd
Journal: J Biol Chem Date: 2004-12-21 Impact factor: 5.157

2. Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture.

Authors: Barbara Giomarelli; Kathryn M Schumacher; Troy E Taylor; Raymond C Sowder; James L Hartley; James B McMahon; Toshiyuki Mori
Journal: Protein Expr Purif Date: 2005-11-07 Impact factor: 1.650

3. Potent anti-HIV activity of scytovirin domain 1 peptide.

Authors: Changyun Xiong; Barry R O'Keefe; R Andrew Byrd; James B McMahon
Journal: Peptides Date: 2006-05-02 Impact factor: 3.750

4. Analysis of sequence requirements for biological activity of cyanovirin-N, a potent HIV (human immunodeficiency virus)-inactivating protein.

Authors: T Mori; R H Shoemaker; R J Gulakowski; B L Krepps; J B McMahon; K R Gustafson; L K Pannell; M R Boyd
Journal: Biochem Biophys Res Commun Date: 1997-09-08 Impact factor: 3.575

5. Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta.

Authors: Kathryn S Jones; Salem Akel; Cari Petrow-Sadowski; Ying Huang; Daniel C Bertolette; Francis W Ruscetti
Journal: J Immunol Date: 2005-04-01 Impact factor: 5.422

6. Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

Authors: M R Boyd; K R Gustafson; J B McMahon; R H Shoemaker; B R O'Keefe; T Mori; R J Gulakowski; L Wu; M I Rivera; C M Laurencot; M J Currens; J H Cardellina; R W Buckheit; P L Nara; L K Pannell; R C Sowder; L E Henderson
Journal: Antimicrob Agents Chemother Date: 1997-07 Impact factor: 5.191

7. In vitro characterization of a koala retrovirus.

Authors: Nidia M Oliveira; Karen B Farrell; Maribeth V Eiden
Journal: J Virol Date: 2006-03 Impact factor: 5.103

8. Cyanovirin-N binds to gp120 to interfere with CD4-dependent human immunodeficiency virus type 1 virion binding, fusion, and infectivity but does not affect the CD4 binding site on gp120 or soluble CD4-induced conformational changes in gp120.

Authors: M T Esser; T Mori; I Mondor; Q J Sattentau; B Dey; E A Berger; M R Boyd; J D Lifson
Journal: J Virol Date: 1999-05 Impact factor: 5.103

5. Viral Evasion of Innate Immune Defense: The Case of Resistance of Pandemic H1N1 Influenza A Virus to Human Mannose-Binding Proteins.

Authors: Mitchell R White; Nikolaos M Nikolaidis; Francis McCormack; Erika C Crouch; Kevan L Hartshorn
Journal: Front Microbiol Date: 2021-12-08 Impact factor: 5.640

5 in total

Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses.

1. Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp.

2. Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture.

3. Potent anti-HIV activity of scytovirin domain 1 peptide.

4. Analysis of sequence requirements for biological activity of cyanovirin-N, a potent HIV (human immunodeficiency virus)-inactivating protein.

5. Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta.

6. Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

7. In vitro characterization of a koala retrovirus.

8. Cyanovirin-N binds to gp120 to interfere with CD4-dependent human immunodeficiency virus type 1 virion binding, fusion, and infectivity but does not affect the CD4 binding site on gp120 or soluble CD4-induced conformational changes in gp120.

9. Suppression of a fusion defect by second site mutations in the ecotropic murine leukemia virus surface protein.

10. Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.

Review 1. Antiviral lectins: Selective inhibitors of viral entry.

Review 2. Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential.

Review 3. Lectins as Promising Therapeutics for the Prevention and Treatment of HIV and Other Potential Coinfections.

4. Engineering recombinantly expressed lectin-based antiviral agents.

5. Viral Evasion of Innate Immune Defense: The Case of Resistance of Pandemic H1N1 Influenza A Virus to Human Mannose-Binding Proteins.