Literature DB >> 12482436

The preparation of (S)-aspartate semi-aldehyde appropriate for use in biochemical studies.

Sarah J Roberts1, Jonathan C Morris, Renwick C J Dobson, Juliet A Gerrard.   

Abstract

We report two three-step syntheses of (S)-aspartate semi-aldehyde, an important synthetic and biosynthetic precursor, from diprotected aspartic acid. The first synthesis proceeds via a thioester, the second via a Weinreb amide. Each route yields pure (S)-aspartate semi-aldehyde in excellent yield. (S)-Aspartate semi-aldehyde prepared in this manner has proved appropriate as a substrate for detailed enzyme studies.

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Year:  2003        PMID： 12482436     DOI： 10.1016/s0960-894x(02)00923-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Crystallization, preliminary X-ray diffraction and structure solution of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti L5-30.

Authors:  Yvonne A Leduc; Christopher P Phenix; Jennifer Puttick; Kurt Nienaber; David R J Palmer; Louis T J Delbaere
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2005-12-16

Review 2.  Cohesion group approach for evolutionary analysis of aspartokinase, an enzyme that feeds a branched network of many biochemical pathways.

Authors:  Chien-Chi Lo; Carol A Bonner; Gary Xie; Mark D'Souza; Roy A Jensen
Journal:  Microbiol Mol Biol Rev       Date:  2009-12       Impact factor: 11.056

3.  Dihydrodipicolinate synthase from Thermotoga maritima.

Authors:  F Grant Pearce; Matthew A Perugini; Hannah J McKerchar; Juliet A Gerrard
Journal:  Biochem J       Date:  2006-12-01       Impact factor: 3.857

4.  Highly efficient biosynthesis of spermidine from L-homoserine and putrescine using an engineered Escherichia coli with NADPH self-sufficient system.

Authors:  Xinxin Liang; Huaxiang Deng; Yajun Bai; Tai-Ping Fan; Xiaohui Zheng; Yujie Cai
Journal:  Appl Microbiol Biotechnol       Date:  2022-08-06       Impact factor: 5.560

5.  Characterization of a thermostable dihydrodipicolinate synthase from Thermoanaerobacter tengcongensis.

Authors:  Suzanne Wolterink-van Loo; Mark Levisson; Maud C Cabrières; Maurice C R Franssen; John van der Oost
Journal:  Extremophiles       Date:  2008-03-15       Impact factor: 2.395

6.  Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase.

Authors:  Renwick C J Dobson; Michael D W Griffin; Sean R A Devenish; F Grant Pearce; Craig A Hutton; Juliet A Gerrard; Geoffrey B Jameson; Matthew A Perugini
Journal:  Protein Sci       Date:  2008-09-11       Impact factor: 6.725

7.  FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Authors:  Miguel Arévalo-Rodríguez; Xuewen Pan; Jef D Boeke; Joseph Heitman
Journal:  Eukaryot Cell       Date:  2004-10

8.  Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde.

Authors:  Renwick C J Dobson; Juliet A Gerrard; F Grant Pearce
Journal:  Biochem J       Date:  2004-02-01       Impact factor: 3.857

9.  Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1.

Authors:  Farah Lamiable-Oulaidi; Rajesh K Harijan; Karl J Shaffer; Douglas R Crump; Yan Sun; Quan Du; Shivali A Gulab; Ashna A Khan; Andreas Luxenburger; Anthony D Woolhouse; Simone Sidoli; Peter C Tyler; Vern L Schramm
Journal:  J Med Chem       Date:  2022-03-24       Impact factor: 8.039

10.  Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana.

Authors:  Michael D W Griffin; Jagan M Billakanti; Akshita Wason; Sabrina Keller; Haydyn D T Mertens; Sarah C Atkinson; Renwick C J Dobson; Matthew A Perugini; Juliet A Gerrard; Frederick Grant Pearce
Journal:  PLoS One       Date:  2012-07-05       Impact factor: 3.240
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