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Literature DB >> 12414681

Extent of hydrogen-bond protection in folded proteins: a constraint on packing architectures.

Abstract

Progressive structuring and ultimately exclusion of water by hydrophobes surrounding backbone hydrogen bonds turn the latter into guiding factors of protein folding. Here we demonstrate that an arrangement of five hydrophobes yields an optimal hydrogen-bond stabilization. This motif is shown to be nearly ubiquitous in native folds.

Entities: Chemical

Mesh：

Substances：
Water

Year: 2002 PMID： 12414681 PMCID： PMC1302333 DOI： 10.1016/S0006-3495(02)75258-2

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

14 in total

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Journal: Protein Sci Date: 2000-11 Impact factor: 6.725

2. D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding.

Authors: B A Krantz; L B Moran; A Kentsis; T R Sosnick
Journal: Nat Struct Biol Date: 2000-01

3. Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects.

Authors: Bryan A Krantz; Alok K Srivastava; Sehat Nauli; David Baker; Robert T Sauer; Tobin R Sosnick
Journal: Nat Struct Biol Date: 2002-06

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Journal: Protein Eng Date: 1998-09

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Journal: Annu Rev Biophys Biomol Struct Date: 1996

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Authors: I Bahar; R L Jernigan
Journal: J Mol Biol Date: 1997-02-14 Impact factor: 5.469

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Journal: Adv Protein Chem Date: 1995

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Journal: Nucleic Acids Res Date: 1994-09 Impact factor: 16.971

9. Physical reasons for the unusual alpha-helix stabilization afforded by charged or neutral polar residues in alanine-rich peptides.

Authors: J A Vila; D R Ripoll; H A Scheraga
Journal: Proc Natl Acad Sci U S A Date: 2000-11-21 Impact factor: 11.205

Review 10. Prions.

Authors: S B Prusiner
Journal: Proc Natl Acad Sci U S A Date: 1998-11-10 Impact factor: 11.205

14 in total

1. Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis.

Authors: Ariel Fernández; R Stephen Berry
Journal: Proc Natl Acad Sci U S A Date: 2003-02-18 Impact factor: 11.205

2. Structural defects and the diagnosis of amyloidogenic propensity.

Authors: Ariel Fernández; József Kardos; L Ridgway Scott; Yuji Goto; R Stephen Berry
Journal: Proc Natl Acad Sci U S A Date: 2003-05-12 Impact factor: 11.205

3. The nonconserved wrapping of conserved protein folds reveals a trend toward increasing connectivity in proteomic networks.

Authors: Ariel Fernández; Ridgway Scott; R Stephen Berry
Journal: Proc Natl Acad Sci U S A Date: 2004-02-20 Impact factor: 11.205

10. Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins.

Authors: Jianmin Gao; Daryl A Bosco; Evan T Powers; Jeffery W Kelly
Journal: Nat Struct Mol Biol Date: 2009-06-14 Impact factor: 15.369