Literature DB >> 1236641

The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide).

G DiPasquale, C Rassaert, R Richter, P Welaj, J Gingold, R Singer.   

Abstract

Isoxicam is a potent, orally active, nonsteroidal anti-inflammarory drug with prolonged activtiy in experimentally induced inflammation in rats. Isoxicam is less ulcerogenic, acutely less toxic and, therefore, appears to have a therapeutic ratio superior to other standard agents to which it was compared.

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Year:  1975        PMID： 1236641     DOI： 10.1007/bf02026440

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  Comparative activities, tolerances and safety of nonsteroidal anti-inflammatory agents in rats.

Authors:  J Wax; C V Winder; D K Tessman; M D Stephens
Journal:  J Pharmacol Exp Ther       Date:  1975-01       Impact factor: 4.030

2.  The anti-inflammatory effects of 4-hydroxy-2-methyl-3-phenylcarbamoyl-2H-1,2-benzothiazine-1,1-dioxide (W7477).

Authors:  G Di Pasquale; C L Rassaert; R S Richter; L V Tripp
Journal:  Arch Int Pharmacodyn Ther       Date:  1973-05

3.  Factors influencing the development of indomethacin-induced intestinal ulcers in the rat.

Authors:  G Volterra; N Pisanti; A Meli
Journal:  Proc Soc Exp Biol Med       Date:  1974-05

4.  Anti-inflammatory and pharmacokinetic properties of sudoxicam N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.

Authors:  E H Wiseman; J Chiaini
Journal:  Biochem Pharmacol       Date:  1972-09-01       Impact factor: 5.858

5.  Antiinflammatory 3,4-dihydro-2-alkyl-3-oxo-2H-1,2-benzothiazine-4-carboxamide 1,1-dioxides.

Authors:  J G Lombardino; E H Wiseman
Journal:  J Med Chem       Date:  1971-10       Impact factor: 7.446

Review 6.  Nonsteroid anti-inflammatory agents.

Authors:  C A Winter
Journal:  Annu Rev Pharmacol       Date:  1966       Impact factor: 13.820

7.  Indomethacin-induced intestinal lesions in the rat.

Authors:  D A Brodie; P G Cook; B J Bauer; G E Dagle
Journal:  Toxicol Appl Pharmacol       Date:  1970-11       Impact factor: 4.219

8.  Effect of betamethasone 17-benzoate and 6 alpha, 9 alpha difluoroprednisolone 21-acetate 17-butyrate on the survival of adrenalectomized rats.

Authors:  G DiPasquale; L Tripp
Journal:  Steroids       Date:  1970-12       Impact factor: 2.668

9.  Perspectives in nonsteroidal anti-inflammatory agents.

Authors:  T Y Shen
Journal:  Angew Chem Int Ed Engl       Date:  1972-06       Impact factor: 15.336

10.  ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.

Authors:  C A WINTER; E A RISLEY; G W NUSS
Journal:  J Pharmacol Exp Ther       Date:  1963-09       Impact factor: 4.030
  10 in total
  5 in total

1.  Comparison between plethysmometer and micrometer methods to measure acute paw oedema for screening anti-inflammatory activity in mice.

Authors:  Jagdish N Sharma; Awatef M Samud; M Zaini Asmawi
Journal:  Inflammopharmacology       Date:  2004       Impact factor: 4.473

2.  Anti-inflammatory activity of isoxicam in combination with aspirin or D-propoxyphene.

Authors:  G DiPasquale; C Rassaert; P Welaj; L Tripp
Journal:  Agents Actions       Date:  1976-11

3.  The in vivo antiinflammatory effects of (E)-2,6-bis(1,1-dimethyl-ethyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethenyl ] phenol (PD 127443) a novel dual inhibitor of 5-lipoxygenase and cyclooxygenase.

Authors:  D J Schrier; M A Adamchak; A M Boctor; C R Kostlan; D L Flynn; J H Jordan; M E Lesch; G C Okonkwo
Journal:  Agents Actions       Date:  1989-06

4.  The effect of isoxicam-aspirin combinations on the polyurethane sponge implantation model in the rat.

Authors:  R Garrett; B Manthey; B Vernon-Roberts; P M Brooks
Journal:  Br J Clin Pharmacol       Date:  1986       Impact factor: 4.335

5.  Metabolic disposition of the non-steroidal anti-inflammatory agent isoxicam in man.

Authors:  T F Woolf; A Black; A Sedman; T Chang
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1992 Jan-Mar       Impact factor: 2.441
  5 in total

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