Literature DB >> 3620271

The effect of isoxicam-aspirin combinations on the polyurethane sponge implantation model in the rat.

R Garrett, B Manthey, B Vernon-Roberts, P M Brooks.   

Abstract

1 Anti-inflammatory effects of isoxicam alone and in combination with aspirin were studied in rats using the polyurethane sponge implantation model of acute inflammation. 2 Dose-response studies were performed to delineate a suppressive (high) and non-suppressive (low) dose of isoxicam prior to studying these doses in combination with aspirin. 3 The results indicate that a combination of aspirin with isoxicam does not have an additive anti-inflammatory effect. 4 The interference demonstrated by aspirin with the anti-inflammatory effects of other NSAIDs such as indomethacin is also demonstrated with aspirin/isoxicam combinations.

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Year:  1986        PMID： 3620271      PMCID： PMC1400970          DOI： 10.1111/j.1365-2125.1986.tb02993.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  18 in total

1.  Interactions of aspirin with nonsteroidal antiinflammatory drugs in man.

Authors:  A Rubin; B E Rodda; P Warrick; C M Gruber; A S Ridolfo
Journal:  Arthritis Rheum       Date:  1973 Sep-Oct

2.  Interaction of aspirin with nonsteroidal anti-inflammatory drugs in rats.

Authors:  Z E Mielens; H P Drobeck; J Rozitis; V J Sansone
Journal:  J Pharm Pharmacol       Date:  1968-07       Impact factor: 3.765

3.  Naproxen-aspirin interactions in man.

Authors:  E J Segre; M Chaplin; E Forchielli; R Runkel; H Sevelius
Journal:  Clin Pharmacol Ther       Date:  1974-04       Impact factor: 6.875

4.  Interactions of aspirin, indomethacin and other drugs in adjuvant-induced arthritis in the rat.

Authors:  C G Van Arman; G W Nuss; E A Risley
Journal:  J Pharmacol Exp Ther       Date:  1973-11       Impact factor: 4.030

5.  Interactions of anti-inflammatory drugs in carrageenan-induced foot edema of the rat.

Authors:  K F Swingle; T J Grant; L W Jaques; D C Kvam
Journal:  J Pharmacol Exp Ther       Date:  1970-04       Impact factor: 4.030

6.  Indomethacin--aspirin interaction: a clinical appraisal.

Authors:  P M Brooks; J J Walker; M A Bell; W W Buchanan; A R Rhymer
Journal:  Br Med J       Date:  1975-07-12

7.  Assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli.

Authors:  A K Clarke; B Vernon-Roberts; H L Currey
Journal:  Ann Rheum Dis       Date:  1975-08       Impact factor: 19.103

8.  Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat.

Authors:  R Garrett; B Manthey; B Vernon-Roberts; P M Brooks
Journal:  Ann Rheum Dis       Date:  1983-08       Impact factor: 19.103

9.  Interaction between flurbiprofen and indomethacin in rheumatoid arthritis.

Authors:  S R Rudge; J K Lloyd-Jones; I D Hind
Journal:  Br J Clin Pharmacol       Date:  1982-03       Impact factor: 4.335

10.  Comparison of the effects of alclofenac, flurbiprofen, and prednisolone on acute inflammatory response in the rat.

Authors:  J Woodland; B Vernon-Roberts; K V Swettenham; H L Currey
Journal:  Ann Rheum Dis       Date:  1977-04       Impact factor: 19.103
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  1 in total

1.  Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA.

Authors:  K D Rainsford; D R Haynes
Journal:  Inflammopharmacology       Date:  2013-07-04       Impact factor: 4.473
  1 in total

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