Literature DB >> 1123722

Comparative activities, tolerances and safety of nonsteroidal anti-inflammatory agents in rats.

J Wax, C V Winder, D K Tessman, M D Stephens.   

Abstract

Relative anti-inflammatory potencies of aspirin, phenylbutazone, indomethacin, three fenamates and several other nonsteroidal anti-inflammatory agents were obtained in several laboratory models of acute and chronic inflammation. Relative toxicities and ulcerogenicities were determined in rats of the same source, strain and sex. The acute ulcerogenic assay measures the minimal irritation potential of these agents and leads to a sensitive index of the safety of such compounds when compared with their therapeutic potencies. By these criteria, meclofenamic acid is a highly potent, acceptably safe and exceptionally well tolerated anti-inflammatory-antipyretic agent in rats when compared with other such drugs.

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Year:  1975        PMID： 1123722

Source DB:  PubMed          Journal:  J Pharmacol Exp Ther        ISSN： 0022-3565            Impact factor:   4.030


  9 in total

Review 1.  Tolmetin: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1978-06       Impact factor: 9.546

2.  A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents.

Authors:  R E Pemberton; L J Strand
Journal:  Dig Dis Sci       Date:  1979-01       Impact factor: 3.199

Review 3.  Nonsteroidal anti-inflammatory agents: species differences in pharmacodynamics.

Authors:  Y Ruckebusch; P L Toutain
Journal:  Vet Res Commun       Date:  1983-12       Impact factor: 2.459

4.  An overview of nonsteroidal antiinflammatory agents (NSAIA).

Authors:  W L Norton; M A Meisinger
Journal:  Inflammation       Date:  1977-03       Impact factor: 4.092

5.  The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide).

Authors:  G DiPasquale; C Rassaert; R Richter; P Welaj; J Gingold; R Singer
Journal:  Agents Actions       Date:  1975-08

6.  Predictability of the clinical potency of NSAIDs from the preclinical pharmacodynamics in rats.

Authors:  A Mukherjee; V G Hale; O Borga; R Stein
Journal:  Inflamm Res       Date:  1996-11       Impact factor: 4.575

7.  The pharmacology of arachidonic acid-induced rat PMN leukocyte infiltration.

Authors:  M J DiMartino; C E Wolff; G K Campbell; N Hanna
Journal:  Agents Actions       Date:  1989-06

8.  The effect of non-steroidal anti-inflammatory drugs on adenosine triphosphate content and histamine release from rat peritoneal cell suspensions rich in mast cells.

Authors:  G D Champion; R O Day; J E Ray; D N Wade
Journal:  Br J Pharmacol       Date:  1977-01       Impact factor: 8.739

9.  Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth.

Authors:  Xingxing Wang; Stephane Budel; Kenneth Baughman; Grahame Gould; Kang-Ho Song; Stephen M Strittmatter
Journal:  J Neurotrauma       Date:  2009-01       Impact factor: 5.269
  9 in total

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